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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.isci.2018.05.010
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dc.titleGeneration of Drosophila sisRNAs by Independent Transcription from Cognate Introns
dc.contributor.authorJia Ng, S.S.
dc.contributor.authorZheng, R.T.
dc.contributor.authorOsman, I.
dc.contributor.authorPek, J.W.
dc.date.accessioned2021-12-16T07:55:50Z
dc.date.available2021-12-16T07:55:50Z
dc.date.issued2018
dc.identifier.citationJia Ng, S.S., Zheng, R.T., Osman, I., Pek, J.W. (2018). Generation of Drosophila sisRNAs by Independent Transcription from Cognate Introns. iScience 4 : 68-75. ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2018.05.010
dc.identifier.issn25890042
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/210875
dc.description.abstractMolecular Biology; Molecular Mechanism of Gene Regulation; Developmental Biology; Transcriptomics © 2018 The Author(s)Although stable intronic sequence RNAs (sisRNAs)are conserved in plants and animals, their functional significance is still unclear. We identify a pool of polyadenylated maternally deposited sisRNAs in Drosophila melanogaster. These sisRNAs can be generated by independent transcription from the cognate introns. The ovary-specific poly(A)polymerase Wispy mediates the polyadenylation of maternal sisRNAs and confers their stability as maternal transcripts. A developmentally regulated sisRNA sisR-3 represses the expression of a long noncoding RNA CR44148 and is required during development. Our results expand the pool of sisRNAs and suggest that sisRNAs perform regulatory functions during development in Drosophila. © 2018 The Author(s)
dc.publisherElsevier Inc.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2018
dc.subjectDevelopmental Biology
dc.subjectMolecular Biology
dc.subjectMolecular Mechanism of Gene Regulation
dc.subjectTranscriptomics
dc.typeArticle
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1016/j.isci.2018.05.010
dc.description.sourcetitleiScience
dc.description.volume4
dc.description.page68-75
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