Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.aat7854
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dc.titleInversion of a large-scale circuit model reveals a cortical hierarchy in the dynamic resting human brain
dc.contributor.authorWang, P.
dc.contributor.authorKong, R.
dc.contributor.authorKong, X.
dc.contributor.authorLiégeois, R.
dc.contributor.authorOrban, C.
dc.contributor.authorDeco, G.
dc.contributor.authorVan Den Heuvel, M.P.
dc.contributor.authorYeo, B.T.T.
dc.date.accessioned2021-12-16T07:53:06Z
dc.date.available2021-12-16T07:53:06Z
dc.date.issued2019
dc.identifier.citationWang, P., Kong, R., Kong, X., Liégeois, R., Orban, C., Deco, G., Van Den Heuvel, M.P., Yeo, B.T.T. (2019). Inversion of a large-scale circuit model reveals a cortical hierarchy in the dynamic resting human brain. Tropical and Subtropical Agroecosystems 21 (3) : eaat7854. ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.aat7854
dc.identifier.issn18700462
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/210836
dc.description.abstractWe considered a large-scale dynamical circuit model of human cerebral cortex with region-specific microscale properties. The model was inverted using a stochastic optimization approach, yielding markedly better fit to new, out-of-sample resting functional magnetic resonance imaging (fMRI) data. Without assuming the existence of a hierarchy, the estimated model parameters revealed a large-scale cortical gradient. At one end, sensorimotor regions had strong recurrent connections and excitatory subcortical inputs, consistent with localized processing of external stimuli. At the opposing end, default network regions had weak recurrent connections and excitatory subcortical inputs, consistent with their role in internal thought. Furthermore, recurrent connection strength and subcortical inputs provided complementary information for differentiating the levels of the hierarchy, with only the former showing strong associations with other macroscale and microscale proxies of cortical hierarchies (meta-analysis of cognitive functions, principal resting fMRI gradient, myelin, and laminarspecific neuronal density). Overall, this study provides microscale insights into a macroscale cortical hierarchy in the dynamic resting brain. © 2019 American Association for the Advancement of Science. All rights reserved.
dc.publisherUniversidad Autonoma de Yucatan
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScopus OA2019
dc.typeArticle
dc.contributor.departmentDEPT OF ELECTRICAL & COMPUTER ENGG
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1126/sciadv.aat7854
dc.description.sourcetitleTropical and Subtropical Agroecosystems
dc.description.volume21
dc.description.issue3
dc.description.pageeaat7854
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