Please use this identifier to cite or link to this item: https://doi.org/10.1177/15593258211057768
Title: Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation
Authors: Guo, Lei
Du, Qian-Qian
Cheng, Piao-Qin
Yang, Ting-Ting
Xing, Chao-Qun
Luo, Xue-Zhi
Peng, Xiao-Chun
Qian, Feng
Huang, Jiang-Rong
Tang, Feng-Ru 
Keywords: Lycium barbarum berry
ionizing radiation
cognitive dysfunction
calbindin
parvalbumin
Issue Date: Oct-2021
Publisher: SAGE Publications
Citation: Guo, Lei, Du, Qian-Qian, Cheng, Piao-Qin, Yang, Ting-Ting, Xing, Chao-Qun, Luo, Xue-Zhi, Peng, Xiao-Chun, Qian, Feng, Huang, Jiang-Rong, Tang, Feng-Ru (2021-10). Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation. Dose-Response 19 (4) : 155932582110577-155932582110577. ScholarBank@NUS Repository. https://doi.org/10.1177/15593258211057768
Abstract: Background: Brain exposure to ionizing radiation during the radiotherapy of brain tumor or metastasis of peripheral cancer cells to the brain has resulted in cognitive dysfunction by reducing neurogenesis in hippocampus. The water extract of Lycium barbarum berry (Lyc), containing water-soluble Lycium barbarum polysaccharides and flavonoids, can protect the neuronal injury by reducing oxidative stress and suppressing neuroinflammation. Reseach Design: To demonstrate the long-term radioprotective effect of Lyc, we evaluated the neurobehavioral alterations and the numbers of NeuN, calbindin (CB), and parvalbumin (PV) immunopositive hippocampal neurons in BALB/c mice after acute 5.5 Gy radiation with/without oral administration of Lyc at the dosage of 10 g/kg daily for 4 weeks. Results: The results showed that Lyc could improve irradiation-induced animal weight loss, depressive behaviors, spatial memory impairment, and hippocampal neuron loss. Immunohistochemistry study demonstrated that the loss of NeuN-immunopositive neuron in the hilus of the dentate gyrus, CB-immunopositive neuron in CA1 strata radiatum, lacunosum moleculare and oriens, and PV-positive neuron in CA1 stratum pyramidum and stratum granulosum of the dentate gyrus after irradiation were significantly improved by Lyc treatment. Conclusion: The neuroprotective effect of Lyc on those hippocampal neurons may benefit the configuration of learning related neuronal networks and then improve radiation induced neurobehavioral changes such as cognitive impairment and depression. It suggests that  Lycium barbarum berry may be an alternative food supplement to prevent radiation-induced neuron loss and neuropsychological disorders.
Source Title: Dose-Response
URI: https://scholarbank.nus.edu.sg/handle/10635/210276
ISSN: 1559-3258
DOI: 10.1177/15593258211057768
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