Please use this identifier to cite or link to this item: https://doi.org/10.3389/fbioe.2018.00090
Title: Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering
Authors: Chu, G.
Shi, C. 
Wang, H.
Zhang, W.
Yang, H.
Li, B.
Keywords: annulus fibrosus
biomolecular therapy
gene therapy
intervertebral disc
mechano-regulation
scaffolds
tissue engineering
tissue regeneration
Issue Date: 2018
Publisher: Frontiers Media S.A.
Citation: Chu, G., Shi, C., Wang, H., Zhang, W., Yang, H., Li, B. (2018). Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering. Frontiers in Bioengineering and Biotechnology 6 : 90. ScholarBank@NUS Repository. https://doi.org/10.3389/fbioe.2018.00090
Rights: Attribution 4.0 International
Abstract: Intervertebral disc (IVD) is an avascular tissue which contributes to the weight bearing, motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due to injury, pathology, and aging. Annulus fibrosus (AF), the structural and functional integrity of which is critically essential to confine nucleus pulpous (NP) and maintain physiological intradiscal pressure under mechanical loading, plays a critical role in the biomechanical properties of IVD. AF degeneration commonly results in substantial deterioration of IVD. During this process, the biomechanical properties of AF and the balance between anabolism and catabolism in IVD are progressively disrupted, leading to chronic back pain, and even disability of individuals. Therefore, repairing and regenerating AF are effective treatments to degeneration-associated pains. However, they remain highly challenging due to the complexity of natural AF tissue in the aspects of cell phenotype, biochemical composition, microstructure, and mechanical properties. Tissue engineering (TE), by combining biological science and materials engineering, shed lights on AF regeneration. In this article, we review recent advances in the pro-anabolic approaches in the form of cell delivery, bioactive factors delivery, gene therapy, and TE strategies for achieving AF regeneration. © Copyright © 2018 Chu, Shi, Wang, Zhang, Yang and Li.
Source Title: Frontiers in Bioengineering and Biotechnology
URI: https://scholarbank.nus.edu.sg/handle/10635/210096
ISSN: 2296-4185
DOI: 10.3389/fbioe.2018.00090
Rights: Attribution 4.0 International
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