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https://doi.org/10.1186/s13756-018-0448-4
Title: | The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model | Authors: | Meir, M. Bifani, P. Barkan, D. |
Keywords: | Avibactam Combination treatment MIC Mycobacterium abscessus Piperacillin |
Issue Date: | 2018 | Publisher: | BioMed Central Ltd. | Citation: | Meir, M., Bifani, P., Barkan, D. (2018). The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model. Antimicrobial Resistance and Infection Control 7 (1) : 151. ScholarBank@NUS Repository. https://doi.org/10.1186/s13756-018-0448-4 | Rights: | Attribution 4.0 International | Abstract: | Treating M. abscessus infection is challenging due to the potent ?-lactamase Bla Mab (Beta-lactamase of M. abscessus ) . Avibactam is a non-?-lactam, ?-lactamase inhibitor shown to inhibit Bla Mab . We tested whether avibactem can render piperacillin effective against M. Abscessus. In-vitro, avibactam enhanced the activity of piperacillin by 16-32 fold, with no significant effect on meropenem. In an in-vivo Galleria mellonella model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect. © 2018 The Author(s). | Source Title: | Antimicrobial Resistance and Infection Control | URI: | https://scholarbank.nus.edu.sg/handle/10635/210073 | ISSN: | 2047-2994 | DOI: | 10.1186/s13756-018-0448-4 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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