Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pbio.2006211
Title: Rods contribute to the light-induced phase shift of the retinal clock in mammals
Authors: Calligaro, Hugo
Coutanson, Christine
Najjar, Raymond P 
Mazzaro, Nadia
Cooper, Howard M
Haddjeri, Nasser
Felder-Schmittbuhl, Marie-Paule
Dkhissi-Benyahya, Ouria
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biology
Life Sciences & Biomedicine - Other Topics
CIRCADIAN CLOCK
GENE-EXPRESSION
MOUSE RETINA
CONE
PHOTORECEPTORS
MELANOPSIN
DOPAMINE
TRANSMISSION
ENTRAINMENT
RESPONSES
Issue Date: 1-Mar-2019
Publisher: PUBLIC LIBRARY SCIENCE
Citation: Calligaro, Hugo, Coutanson, Christine, Najjar, Raymond P, Mazzaro, Nadia, Cooper, Howard M, Haddjeri, Nasser, Felder-Schmittbuhl, Marie-Paule, Dkhissi-Benyahya, Ouria (2019-03-01). Rods contribute to the light-induced phase shift of the retinal clock in mammals. PLOS BIOLOGY 17 (3). ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pbio.2006211
Abstract: While rods, cones, and intrinsically photosensitive melanopsin-containing ganglion cells (ipRGCs) all drive light entrainment of the master circadian pacemaker of the suprachiasmatic nucleus, recent studies have proposed that entrainment of the mouse retinal clock is exclusively mediated by a UV-sensitive photopigment, neuropsin (OPN5). Here, we report that the retinal circadian clock can be phase shifted by short duration and relatively low-irradiance monochromatic light in the visible part of the spectrum, up to 520 nm. Phase shifts exhibit a classical photon dose-response curve. Comparing the response of mouse models that specifically lack middle-wavelength (MW) cones, melanopsin, and/or rods, we found that only the absence of rods prevented light-induced phase shifts of the retinal clock, whereas light-induced phase shifts of locomotor activity are normal. In a “rod-only” mouse model, phase shifting response of the retinal clock to light is conserved. At shorter UV wavelengths, our results also reveal additional recruitment of short-wavelength (SW) cones and/ or OPN5. These findings suggest a primary role of rod photoreceptors in the light response of the retinal clock in mammals.
Source Title: PLOS BIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/209736
ISSN: 15449173
15457885
DOI: 10.1371/journal.pbio.2006211
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