Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsomega.8b01448
Title: Polymer-Based Accurate Positioning: An Exact Worm-like-Chain Study
Authors: Hou, R.
Wang, N.
Bao, W. 
Wang, Z. 
Issue Date: 2018
Publisher: American Chemical Society
Citation: Hou, R., Wang, N., Bao, W., Wang, Z. (2018). Polymer-Based Accurate Positioning: An Exact Worm-like-Chain Study. ACS Omega 3 (10) : 14318-14326. ScholarBank@NUS Repository. https://doi.org/10.1021/acsomega.8b01448
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Precise positioning of molecular objects from one location to another is important for nanomanipulation and is also involved in molecular motors. Here, we study single-polymer-based positioning on the basis of the exact solution to the realistic three-dimensional worm-like-chain (WLC) model. The results suggest the possibility of a surprisingly accurate flyfishing-like positioning in which tilting one end of a flexible short polymer enables positioning of the other diffusing end to a distant location within an error of ?1 nm. This offers a new mechanism for designing molecular positioning devices. The flyfishing effect (and reverse process) likely plays a role in biological molecular motors and may be used to improve speed of artificial counterparts. To facilitate these applications, a new force-extension formula is obtained from the exact WLC solution. This formula has an improved accuracy over the widely used Marko-Siggia formula for stretched polymers and is valid for compressed polymers too. The new formula is useful in analysis of single-molecule stretching experiments and in estimating intramolecular forces of molecular motors, especially those involving both stretched and compressed polymer components. © Copyright 2018 American Chemical Society.
Source Title: ACS Omega
URI: https://scholarbank.nus.edu.sg/handle/10635/209650
ISSN: 2470-1343
DOI: 10.1021/acsomega.8b01448
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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