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Title: Enantioselective additions of fluorocarbon nucleophiles using bifunctional organic catalysts
Authors: HAN XIAO
Keywords: asymmetric synthesis, fluorination, organocatalysis, quaternary stereocenters
Issue Date: 13-Aug-2010
Citation: HAN XIAO (2010-08-13). Enantioselective additions of fluorocarbon nucleophiles using bifunctional organic catalysts. ScholarBank@NUS Repository.
Abstract: Catalytic synthesis of chiral fluorinated quaternary carbon centers is a very challenging task and has drawn much attention in recent years. Bifunctional organic molecules are remarkable useful organocatalysts in a wide range of organic reactions. In our work, novel Tryptophan-derived bifunctional thiourea catalysts and Cinchona alkaloid-based bifunctional guanidine catalysts have been developed. Catalytic study on these catalysts towards enantioselective additions of fluorocarbon nucleophiles to afford fluorinated chiral molecules containing vicinal quaternary and tertiary stereogenic centers with exceptional enantioselectivity are also performed.
Appears in Collections:Ph.D Theses (Open)

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