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Title: Development of hollow ferrogadolinium nanonetworks for dual-modal MRI guided cancer chemotherapy
Authors: Tang, T.
Sun, X. 
Xu, X.
Bian, Y.
Ma, X.
Chen, N.
Issue Date: 2019
Publisher: Royal Society of Chemistry
Citation: Tang, T., Sun, X., Xu, X., Bian, Y., Ma, X., Chen, N. (2019). Development of hollow ferrogadolinium nanonetworks for dual-modal MRI guided cancer chemotherapy. RSC Advances 9 (5) : 2559-2566. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial 4.0 International
Abstract: The development of hollow ferrogadolinium nanonetworks has not been reported for nanomedicine application until now. In this study, we developed a hollow and porous ferrogadolinium nanonetwork structure using the one-pot solvothermal method. This nanoparticle could be simultaneously used as a T 1 and T 2 dual-modal magnetic resonance imaging (MRI) contrast agent. In addition, the hollow lumen and abundant pores of the nanonetworks maximized the loading capacity and conferred the nanoplatforms for suitable anticancer drug loading capacity. Using these nanonetworks, MRI and anticancer experiments were conducted in vitro and satisfactory dual-modal MRI and cancer chemotherapy results were obtained. Therefore, the nanonetworks with dual-modal MRI and drug loading abilities effectively complement the ferrogadolinium composites' library and hold great promise in nanomedicine for simultaneous cancer diagnosis and chemotherapy. © 2019 The Royal Society of Chemistry.
Source Title: RSC Advances
ISSN: 2046-2069
DOI: 10.1039/c8ra09102a
Rights: Attribution-NonCommercial 4.0 International
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