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Title: Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells
Authors: Abouleila, Y.
Onidani, K.
Ali, A.
Shoji, H.
Kawai, T.
Lim, C.T. 
Kumar, V.
Okaya, S.
Kato, K.
Hiyama, E.
Yanagida, T.
Masujima, T.
Shimizu, Y.
Honda, K.
Keywords: cancer biomarker
circulating tumor cells
liquid biopsy
mass spectrometry
single cell analysis
Issue Date: 2019
Publisher: Blackwell Publishing Ltd
Citation: Abouleila, Y., Onidani, K., Ali, A., Shoji, H., Kawai, T., Lim, C.T., Kumar, V., Okaya, S., Kato, K., Hiyama, E., Yanagida, T., Masujima, T., Shimizu, Y., Honda, K. (2019). Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells. Cancer Science 110 (2) : 697-706. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Recently, there has been increased attention on the analysis of circulating tumor cells (CTCs), also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. Circulating tumor cells are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Existing methods lack sensitivity, specificity, or reproducibility required in CTC characterization and detection. Here, we report untargeted molecular profiling of single CTCs obtained from gastric cancer and colorectal cancer patients, using live single cell mass spectrometry integrated with microfluidics-based cell enrichment techniques. Using this approach, we showed the difference in the metabolomic profile between CTCs originating from different cancer groups. Moreover, potential biomarkers were putatively annotated to be specific to each cancer type. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
Source Title: Cancer Science
ISSN: 1347-9032
DOI: 10.1111/cas.13915
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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