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Title: Derivation of mimetic ?? T cells endowed with cancer recognition receptors from reprogrammed ?? T cell
Authors: Zeng, J.
Tang, S.Y. 
Wang, S. 
Issue Date: 2019
Publisher: Public Library of Science
Citation: Zeng, J., Tang, S.Y., Wang, S. (2019). Derivation of mimetic ?? T cells endowed with cancer recognition receptors from reprogrammed ?? T cell. PLoS ONE 14 (5) : e0216815. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used ?? T cell-derived CAR-modified iPSCs to produce CAR-T cells. However, these ?? T cells are restricted to autologous use and only recognize single cancer antigen. To make CAR-T alternative for allogeneic use, we reprogrammed ?? T cell into iPSCs (?? T-iPSCs) to circumvent the risk of graft-versus-host disease. To target multiple cancer-associated antigens, we used an “NK cell-promoting” protocol to differentiate ?? T-iPSCs and to induce expression of natural killer receptors (NKRs). Through such two-step strategy, mimetic ?? T cells endowed with an array of NKRs and thus designated as “?? natural killer T (?? NKT) cells” were derived. With no/low-level expression of inhibitory killer cell immunoglobulin-like receptors (KIRs) and immune checkpoint receptors, ?? NKT cells may provide a potent “off-the-shelf” cytotoxic cell source to recognize multiple ubiquitous antigens in a broad spectrum of cancers. © 2019 Zeng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0216815
Rights: Attribution 4.0 International
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