Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.redox.2018.11.018
Title: Gene expression analysis of heat-shock proteins and redox regulators reveals combinatorial prognostic markers in carcinomas of the gastrointestinal tract
Authors: Pohl, S.Ö.-G.
Pervaiz, S. 
Dharmarajan, A.
Agostino, M.
Keywords: Gastrointestinal carcinomas
Gene expression analysis
Heat shock proteins (HSPs)
Redox regulators
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Pohl, S.Ö.-G., Pervaiz, S., Dharmarajan, A., Agostino, M. (2019). Gene expression analysis of heat-shock proteins and redox regulators reveals combinatorial prognostic markers in carcinomas of the gastrointestinal tract. Redox Biology 25 : 101060. ScholarBank@NUS Repository. https://doi.org/10.1016/j.redox.2018.11.018
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Heat shock proteins (HSPs) are a large family of ubiquitously expressed proteins with diverse functions, including protein assembly and folding/unfolding. These proteins have been associated with the progression of various gastrointestinal tumours. Dysregulation of cellular redox has also been associated with gastrointestinal carcinogenesis, however, a link between HSPs and dysregulation of cellular redox in carcinogenesis remains unclear. In this study, we analysed mRNA co-expression and methylation patterns, as well as performed survival analysis and gene set enrichment analysis, on gastrointestinal cancer data sets (oesophageal, stomach and colorectal carcinomas) to determine whether HSP activity and cellular redox dysregulation are linked. A widespread relationship between HSPs and cellular redox was identified, with specific combinatorial co-expression patterns demonstrated to significantly alter patient survival outcomes. This comprehensive analysis provides the foundation for future studies aimed at deciphering the mechanisms of cooperativity between HSPs and redox regulatory enzymes, which may be a target for future therapeutic intervention for gastrointestinal tumours. © 2018 The Authors
Source Title: Redox Biology
URI: https://scholarbank.nus.edu.sg/handle/10635/209564
ISSN: 2213-2317
DOI: 10.1016/j.redox.2018.11.018
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1016_j_redox_2018_11_018.pdf11.51 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

8
checked on Jan 25, 2023

Page view(s)

77
checked on Jan 26, 2023

Download(s)

3
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons