Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijerph16245148
Title: Diet, secondhand smoke, and glycated hemoglobin (HbA1c) levels among Singapore Chinese adults
Authors: Moore, B.F.
Butler, L.M.
Bachand, A.M.
Salim, A.
Reynolds, S.J.
Wang, R.
Nelson, T.L.
Peel, J.L.
Murphy, S.E.
Koh, W.-P. 
Yuan, J.-M.
Clark, M.L.
Keywords: Antioxidants
Cotinine
Diet
HbA1c
Interaction
Omega-3 polyunsaturated fatty acids
Issue Date: 2019
Publisher: MDPI AG
Citation: Moore, B.F., Butler, L.M., Bachand, A.M., Salim, A., Reynolds, S.J., Wang, R., Nelson, T.L., Peel, J.L., Murphy, S.E., Koh, W.-P., Yuan, J.-M., Clark, M.L. (2019). Diet, secondhand smoke, and glycated hemoglobin (HbA1c) levels among Singapore Chinese adults. International Journal of Environmental Research and Public Health 16 (24) : 5148. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph16245148
Rights: Attribution 4.0 International
Abstract: The combination of poor diet and exposure to secondhand smoke may increase hemoglobin A1c (HbA1c) levels, but few studies have explored this interaction. We explored an interaction among 574 never-smoking adults from the Singapore Chinese Health Study. At baseline (age 59 ± 8 years), intakes of omega-3 polyunsaturated fatty acids, vitamin C, vitamin E and fiber were estimated using a modified food frequency questionnaire. At follow-up (age 64 ± 9 years), HbA1c and cotinine were measured. A product term between cotinine (above or below the median value) and each nutrient (high or low intake) was included in separate linear regression models with HbA1c as the outcome. HbA1c among those with high cotinine and low omega-3 polyunsaturated fatty acids intakes were higher than would be expected due to the individual effects alone (p-for-interaction = 0.05). Among those with lower intakes of omega-3 polyunsaturated fatty acids, high cotinine levels were associated with 0.54% higher HbA1c levels (95% confidence interval [CI]: 0.02, 1.06). Conversely, among those with higher intakes of omega-3 polyunsaturated fatty acids, HbA1c differ not differ by exposure (?0.09%; 95% CI: ?0.45, 0.30). No evidence of interaction was observed for other nutrients. Diets high in omega-3 polyunsaturated fatty acids may ameliorate secondhand smoke-induced increases in HbA1c. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Environmental Research and Public Health
URI: https://scholarbank.nus.edu.sg/handle/10635/209500
ISSN: 1661-7827
DOI: 10.3390/ijerph16245148
Rights: Attribution 4.0 International
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