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https://doi.org/10.1002/ijc.30150
| Title: | Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer | Authors: | Shi, Jiajun Zhang, Yanfeng Zheng, Wei Michailidou, Kyriaki Ghoussaini, Maya Bolla, Manjeet K Wang, Qin Dennis, Joe Lush, Michael Milne, Roger L Shu, Xiao-Ou Beesley, Jonathan Kar, Siddhartha Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Beckmann, Matthias W Zhao, Zhiguo Guo, Xingyi Benitez, Javier Beeghly-Fadiel, Alicia Blot, William Bogdanova, Natalia V Bojesen, Stig E Brauch, Hiltrud Brenner, Hermann Brinton, Louise Broeks, Annegien Bruening, Thomas Burwinkel, Barbara Cai, Hui Canisius, Sander Chang-Claude, Jenny Choi, Ji-Yeob Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Darabi, Hatef Devilee, Peter Droit, Arnaud Dork, Thilo Fasching, Peter A Fletcher, Olivia Flyger, Henrik Fostira, Florentia Gaborieau, Valerie Garcia-Closas, Montserrat Giles, Graham G Grip, Mervi Guenel, Pascal Haiman, Christopher A Hamann, Ute Hartman, Mikael Miao, Hui Hollestelle, Antoinette Hopper, John L Hsiung, Chia-Ni Investigators, KConFab Ito, Hidemi Jakubowska, Anna Johnson, Nichola Torres, Diana Kabisch, Maria Kang, Daehee Khan, Sofia Knight, Julia A Kosma, Veli-Matti Lambrechts, Diether Li, Jingmei Lindblom, Annika Lophatananon, Artitaya Lubinski, Jan Mannermaa, Arto Manoukian, Siranoush Le Marchand, Loic Margolin, Sara Marme, Frederik Matsuo, Keitaro McLean, Catriona Meindl, Alfons Muir, Kenneth Neuhausen, Susan L Nevanlinna, Heli Nord, Silje Borresen-Dale, Anne-Lise Olson, Janet E Orr, Nick van den Ouweland, Ans MW Peterlongo, Paolo Putti, Thomas Choudary Rudolph, Anja Sangrajrang, Suleeporn Sawyer, Elinor J Schmidt, Marjanka K Schmutzler, Rita K Shen, Chen-Yang Hou, Ming-Feng Shrubsole, Matha J Southey, Melissa C Swerdlow, Anthony Teo, Soo Hwang Thienpont, Bernard Toland, Amanda E Tollenaar, Robert AEM Tomlinson, Ian Truong, Therese Tseng, Chiu-Chen Wen, Wanqing Winqvist, Robert Wu, Anna H Yip, Cheng Har Zamora, Pilar M Zheng, Ying Floris, Giuseppe Cheng, Ching-Yu Hooning, Maartje J Martens, John WM Seynaeve, Caroline Kristensen, Vessela N Hall, Per Pharoah, Paul DP Simard, Jacques Chenevix-Trench, Georgia Dunning, Alison M Antoniou, Antonis C Easton, Douglas F Cai, Qiuyin Long, Jirong |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology breast cancer genetic susceptibility 8q24 fine-mapping single nucleotide polymorphism GENOME-WIDE ASSOCIATION SUSCEPTIBILITY LOCI COLORECTAL-CANCER ANALYSES REVEAL GENE DESERT C-MYC EXPRESSION FOXA1 AMPLIFICATION DETERMINANT |
Issue Date: | 15-Sep-2016 | Publisher: | WILEY | Citation: | Shi, Jiajun, Zhang, Yanfeng, Zheng, Wei, Michailidou, Kyriaki, Ghoussaini, Maya, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Milne, Roger L, Shu, Xiao-Ou, Beesley, Jonathan, Kar, Siddhartha, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W, Zhao, Zhiguo, Guo, Xingyi, Benitez, Javier, Beeghly-Fadiel, Alicia, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Broeks, Annegien, Bruening, Thomas, Burwinkel, Barbara, Cai, Hui, Canisius, Sander, Chang-Claude, Jenny, Choi, Ji-Yeob, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Devilee, Peter, Droit, Arnaud, Dork, Thilo, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Gaborieau, Valerie, Garcia-Closas, Montserrat, Giles, Graham G, Grip, Mervi, Guenel, Pascal, Haiman, Christopher A, Hamann, Ute, Hartman, Mikael, Miao, Hui, Hollestelle, Antoinette, Hopper, John L, Hsiung, Chia-Ni, Investigators, KConFab, Ito, Hidemi, Jakubowska, Anna, Johnson, Nichola, Torres, Diana, Kabisch, Maria, Kang, Daehee, Khan, Sofia, Knight, Julia A, Kosma, Veli-Matti, Lambrechts, Diether, Li, Jingmei, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Le Marchand, Loic, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro, McLean, Catriona, Meindl, Alfons, Muir, Kenneth, Neuhausen, Susan L, Nevanlinna, Heli, Nord, Silje, Borresen-Dale, Anne-Lise, Olson, Janet E, Orr, Nick, van den Ouweland, Ans MW, Peterlongo, Paolo, Putti, Thomas Choudary, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Shen, Chen-Yang, Hou, Ming-Feng, Shrubsole, Matha J, Southey, Melissa C, Swerdlow, Anthony, Teo, Soo Hwang, Thienpont, Bernard, Toland, Amanda E, Tollenaar, Robert AEM, Tomlinson, Ian, Truong, Therese, Tseng, Chiu-Chen, Wen, Wanqing, Winqvist, Robert, Wu, Anna H, Yip, Cheng Har, Zamora, Pilar M, Zheng, Ying, Floris, Giuseppe, Cheng, Ching-Yu, Hooning, Maartje J, Martens, John WM, Seynaeve, Caroline, Kristensen, Vessela N, Hall, Per, Pharoah, Paul DP, Simard, Jacques, Chenevix-Trench, Georgia, Dunning, Alison M, Antoniou, Antonis C, Easton, Douglas F, Cai, Qiuyin, Long, Jirong (2016-09-15). Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. INTERNATIONAL JOURNAL OF CANCER 139 (6) : 1303-1317. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.30150 | Abstract: | Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724–129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93–0.97, conditional p = 5.8 × 10−6), rs7815245 (OR = 0.94, 95% CI = 0.91–0.96, conditional p = 1.1 × 10−6) and rs2033101 (OR = 1.05, 95% CI = 1.02–1.07, conditional p = 1.1 × 10−4) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r2 = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry. | Source Title: | INTERNATIONAL JOURNAL OF CANCER | URI: | https://scholarbank.nus.edu.sg/handle/10635/209196 | ISSN: | 00207136 10970215 |
DOI: | 10.1002/ijc.30150 |
| Appears in Collections: | Staff Publications Elements |
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