Please use this identifier to cite or link to this item: https://doi.org/10.22540/JFSF-06-025
Title: Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore.
Authors: Afandy, Nathania Octaviani
Lock, Hui Shan
Tay, Laura 
Yeo, Audrey
Yew, Suzanne
Leung, Bernard P 
Lim, Wee Shiong 
Keywords: Body composition
Dickkopf-1
Monocyte chemotactic protein-1
Sarcopenia
Sarcopenic obesity
Issue Date: Mar-2021
Publisher: Hylonome Publications
Citation: Afandy, Nathania Octaviani, Lock, Hui Shan, Tay, Laura, Yeo, Audrey, Yew, Suzanne, Leung, Bernard P, Lim, Wee Shiong (2021-03). Association of Monocyte Chemotactic Protein-1 and Dickkopf-1 with Body Composition and Physical Performance in Community-Dwelling Older Adults in Singapore.. J Frailty Sarcopenia Falls 6 (1) : 25-31. ScholarBank@NUS Repository. https://doi.org/10.22540/JFSF-06-025
Abstract: Objective: We aim to determine the association of monocyte chemotactic protein-1 (MCP-1) and dickkopft-1 (DKK-1) as potential biomarkers that may predict changes in body composition and physical performance in healthy older adults from Singapore. Methods: Two-hundred community-dwelling older adults (mean age: 67.9 years; 68.5% females) were classified into elevated versus non-elevated groups based on quintile cut-offs of MCP-1 and DKK-1 levels (156.02 pg/mL and 606.31 pg/mL, respectively). Multiple linear regression was performed to examine the relationship between MCP-1 and DKK-1 with body composition and physical performance, adjusted for age, gender and ethnicity. Results: MCP-1 was significantly associated with higher fat mass, fat mass index, percentage body fat, waist circumference and trunk-limb ratio for fat mass (all p<0.01), and repeated chair stand (p=0.004). DKK-1 was not associated with body composition and physical performance measures. Utilising the Asian Working Group for Sarcopenia (AWGS) 2019 criteria, there were 39 (19.5%) sarcopenia and 161 (80.5%) non-sarcopenia participants respectively, with MCP-1 levels significantly higher in sarcopenia compared with non-sarcopenia (p=0.046), but not for DKK-1 (p=0.525). Conclusions: Elevated MCP-1 are associated with changes in fat composition, physical performance and sarcopenia, suggesting its usefulness in identifying at-risk group with sarcopenic obesity.
Source Title: J Frailty Sarcopenia Falls
URI: https://scholarbank.nus.edu.sg/handle/10635/209060
ISSN: 24594148
DOI: 10.22540/JFSF-06-025
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