Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/208993
Title: DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTES FROM PATIENT-DERIVED WHARTON’S JELLY MESENCHYMAL STEM CELLS
Authors: JEAN JACQUES CLEMENT FATIEN
ORCID iD:   orcid.org/0000-0002-1282-3587
Keywords: adipogenesis, wharton’s jelly, diabetes, MSC, white adipocytes, brown adipocytes
Issue Date: 20-Aug-2019
Citation: JEAN JACQUES CLEMENT FATIEN (2019-08-20). DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTES FROM PATIENT-DERIVED WHARTON’S JELLY MESENCHYMAL STEM CELLS. ScholarBank@NUS Repository.
Abstract: Offspring from women with gestational diabetes mellitus (GDM) display elevated rates and earlier onsets of obesity and type 2 diabetes (T2D) compared to children born to non-GDM mothers, epigenetic imprinting by prenatal uterine environment is likely to be involved. Human adipose tissue comprises white and brown adipocytes. Due to the key role of adipose tissue in energy homeostasis, assessing the white and brown adipogenic potential of Wharton’s jelly MSCs (WJ-MSCs) could bring about predictive tools to detect newborns with increased obesity and diabetes risks. It could constitute a model for adipose tissue development mechanistic studies and for the development of new therapeutic strategies against obesity and T2D. This work focuses on the optimization of both white and brown differentiation protocols for WJ-MSCs. Drastic improvement of white adipogenesis was achieved and applied to a four patients comparison. Insights gained on the differentiation of WJ-MSCs will help achieving significant brown adipocyte differentiation.
URI: https://scholarbank.nus.edu.sg/handle/10635/208993
Appears in Collections:Master's Theses (Open)

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