Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00428-019-02619-4
Title: SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations
Authors: Wong, Soon Boon Justin 
Nga, Min En 
Michal, Michal
Vanecek, Tomas
Seet, Ju Ee
Petersson, Fredrik 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pathology
Papillary thyroid carcinoma
Fibromatosis
fasciitis-like stroma
SOX11
beta-Catenin
BRAF
Mutation
FASCIITIS-LIKE STROMA
AGGRESSIVE FIBROMATOSIS
Issue Date: 1-Oct-2019
Publisher: SPRINGER
Citation: Wong, Soon Boon Justin, Nga, Min En, Michal, Michal, Vanecek, Tomas, Seet, Ju Ee, Petersson, Fredrik (2019-10-01). SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations. VIRCHOWS ARCHIV 475 (4) : 519-525. ScholarBank@NUS Repository. https://doi.org/10.1007/s00428-019-02619-4
Abstract: We describe a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma (PTC-FLS) that contained the rare BRAF c.1799_1801delTGA (p.V600_K601delinsE) mutation, which has not previously been reported in this tumour, as well as the CTNNB1 c.133T>C (p.S45P) mutation. We also report the novel observation that spindle cells of the mesenchymal component exhibit diffuse nuclear but not cytoplasmic expression of SOX11, whereas the malignant epithelial cells did not. This suggests that immunoreactivity for SOX11 can be an alternative diagnostic tool for evaluating cases of PTC-FLS where the nuclear expression of β-catenin is ambiguous.
Source Title: VIRCHOWS ARCHIV
URI: https://scholarbank.nus.edu.sg/handle/10635/208878
ISSN: 09456317
14322307
DOI: 10.1007/s00428-019-02619-4
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