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https://doi.org/10.1007/s00428-019-02619-4
Title: | SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations | Authors: | Wong, Soon Boon Justin Nga, Min En Michal, Michal Vanecek, Tomas Seet, Ju Ee Petersson, Fredrik |
Keywords: | Science & Technology Life Sciences & Biomedicine Pathology Papillary thyroid carcinoma Fibromatosis fasciitis-like stroma SOX11 beta-Catenin BRAF Mutation FASCIITIS-LIKE STROMA AGGRESSIVE FIBROMATOSIS |
Issue Date: | 1-Oct-2019 | Publisher: | SPRINGER | Citation: | Wong, Soon Boon Justin, Nga, Min En, Michal, Michal, Vanecek, Tomas, Seet, Ju Ee, Petersson, Fredrik (2019-10-01). SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations. VIRCHOWS ARCHIV 475 (4) : 519-525. ScholarBank@NUS Repository. https://doi.org/10.1007/s00428-019-02619-4 | Abstract: | We describe a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma (PTC-FLS) that contained the rare BRAF c.1799_1801delTGA (p.V600_K601delinsE) mutation, which has not previously been reported in this tumour, as well as the CTNNB1 c.133T>C (p.S45P) mutation. We also report the novel observation that spindle cells of the mesenchymal component exhibit diffuse nuclear but not cytoplasmic expression of SOX11, whereas the malignant epithelial cells did not. This suggests that immunoreactivity for SOX11 can be an alternative diagnostic tool for evaluating cases of PTC-FLS where the nuclear expression of β-catenin is ambiguous. | Source Title: | VIRCHOWS ARCHIV | URI: | https://scholarbank.nus.edu.sg/handle/10635/208878 | ISSN: | 09456317 14322307 |
DOI: | 10.1007/s00428-019-02619-4 |
Appears in Collections: | Staff Publications Elements |
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