Please use this identifier to cite or link to this item: https://doi.org/10.1161/CIRCULATIONAHA.118.038840
Title: Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial
Authors: Steg, Philippe Gabriel
Szarek, Michael
Bhatt, Deepak L
Bittner, Vera A
Bregeault, Marie-France
Dalby, Anthony J
Diaz, Rafael
Edelberg, Jay M
Goodman, Shaun G
Hanotin, Corinne
Harrington, Robert A
Jukema, J Wouter
Lecorps, Guillaume
Mahaffey, Kenneth W
Moryusef, Angele
Ostadal, Petr
Parkhomenko, Alexander
Pordy, Robert
Roe, Matthew T
Tricoci, Pierluigi
Vogel, Robert
White, Harvey D
Zeiher, Andreas M
Schwartz, Gregory G
Sasiela, William J
Tamby, Jean-Francois
Aylward, Philip E
Drexel, Heinz
Sinnaeve, Peter
Dilic, Mirza
Gotcheva, Nina N
Goodman, Shaun G
Prieto, Juan-Carlos
Yong, Huo
Lopez-Jaramillo, Patricio
Pecin, Ivan
Reiner, Zeljko
Ostadal, Petr
Poulsen, Steen Hvitfeldt
Viigimaa, Margus
Nieminen, Markku S
Danchin, Nicolas
Chumburidze, Vakhtang
Marx, Nikolaus
Liberopoulos, Evangelos
Valdovinos, Pablo Carlos Montenegro
Tse, Hung-Fat
Kiss, Robert Gabor
Xavier, Denis
Zahger, Doron
Valgimigli, Marco
Kimura, Takeshi
Kim, Hyo Soo
Kim, Sang-Hyun
Kedev, Sasko
Erglis, Andrejs
Laucevicius, Aleksandras
Yusoff, Khalid
Lopez, Ramos
Ramos Lopez, Gabriel Arturo
Alings, Marco
Halvorsen, Sigrun
Correa Flores, Roger M
Sy, Rody G
Budaj, Andrzej
Morais, Joao
Dorobantu, Maria
Karpov, Yuri
Ristic, Arsen D
Chua, Terrance
Murin, Jan
Fras, Zlatko
Dalby, Anthony J
Tunon, Jose
de Silva, H Asita
Hagstrom, Emil
Muller, Christian
Chiang, Chern-En
Sritara, Piyamitr
Guneri, Sema
Parkhomenko, Alexander
Ray, Kausik K
Moriarty, Patrick M
Roe, Matthew T
Chaitman, Bernard
Kelsey, Sheryl F
Olsson, Anders G
Rouleau, Jean-Lucien
Simoons, Maarten L
Alexander, Karen
Meloni, Chiara
Rosenson, Robert
Sijbrands, Eric JG
Alexander, John H
Armaganijan, Luciana
Bagai, Akshay
Bahit, Maria Cecilia
Brennan, J Matthew
Clifton, Shaun
DeVore, Adam D
Deloatch, Shalonda
Dickey, Sheila
Dombrowski, Keith
Ducrocq, Gregory
Eapen, Zubin
Endsley, Patricia
Eppinger, Arleen
Harrison, Robert W
Hess, Connie Ng
Hlatky, Mark A
Jordan, Joseph Dedrick
Knowles, Joshua W
Kolls, Bradley J
Kong, David F
Leonardi, Sergio
Lillis, Linda
Maron, David J
Marcus, Jill
Mathews, Robin
Mehta, Rajendra H
Mentz, Robert J
Moreira, Humberto Graner
Patel, Chetan B
Pereira, Sabrina Bernardez
Perkins, Lynn
Povsic, Thomas J
Puymirat, Etienne
Jones, William Schuyler
Shah, Bimal R
Sherwood, Matthew W
Stringfellow, Kenya
Sujjavanich, Darin
Toma, Mustafa
Van Diepen, Sean FP
Wilson, Matthew D
Yan, Andrew Tze-Kay
Lopes, Renato D
Trotter, Charlene
Schiavi, Lilia B
Garrido, Marcelo
Alvarisqueta, Andres F
Sassone, Sonia A
Bordonava, Anselmo P
Alves De Lima, Alberto E
Schmidberg, Jorge M
Duronto, Ernesto A
Caruso, Orlando C
Novaretto, Leonardo P
Angel Hominal, Miguel
Montana, Oscar R
Caccavo, Alberto
Gomez Vilamajo, Oscar A
Lorenzatti, Alberto J
Cartasegna, Luis R
Paterlini, Gustavo A
Mackinnon, Ignacio J
Caime, Guillermo D
Amuchastegui, Marcos
Salomone, Rodolfo
Codutti, Oscar R
Jure, Horacio O
Bono, Julio OE
Hrabar, Adrian D
Vallejos, Julio A
Ahuad Guerrero, Rodolfo A
Novoa, Federico
Patocchi, Cristian A
Zaidman, Cesar J
Giuliano, Maria E
Dran, Ricardo D
Vico, Marisa L
Carnero, Gabriela S
Guzman, Pablo N
Medrano Allende, Juan C
Garcia Brasca, Daniela F
Bustamante Labarta, Miguel H
Nani, Sebastian
Blumberg, Eduardo DS
Colombo, Hugo R
Liberman, Alberto
Luciardi, Hector L
Waisman, Gabriel D
Berli, Mario A
Duran, Ruben O Garcia
Cestari, Horacio G
Luquez, Hugo A
Giordano, Jorge A
Saavedra, Silvia S
Zapata, Gerardo
Costamagna, Osvaldo
Llois, Susana
Waites, Jonathon H
Collins, Nicholas
Soward, Allan
Aylward, Philip E
Hii, Chris LS
Shaw, James
Arstall, Margaret A
Horowitz, John
Rogers, James F
Colquhoun, David
Oqueli Flores, Romulo E
Roberts-Thomson, Philip
Raffel, Owen
Lehman, Sam J
Aroney, Constantine
Coverdale, Steven GM
Garrahy, Paul J
Starmer, Gregory
Sader, Mark
Carroll, Patrick A
Dick, Ronald
Zweiker, Robert
Hoppe, Uta
Huber, Kurt
Berger, Rudolf
Weidinger, Franz
Faes, Dirk
Hermans, Kurt
Pirenne, Bruno
Leone, Attilio
Hoffer, Etienne
Vrolix, Mathias CM
De Wolf, Luc
Wollaert, Bart
Castadot, Marc
Dujardin, Karl
Beauloye, Christophe
Vervoort, Geert
Striekwold, Harry
Convens, Carl
Roosen, John
Barbato, Emanuele
Claeys, Marc
Cools, Frank
Terzic, Ibrahim
Barakovic, Fahir
Midzic, Zlatko
Pojskic, Belma
Fazlibegovic, Emir
Durak-Nalbantic, Azra
Vulic, Dusko
Muslibegovic, Adis
Goronja, Boris
Reis, Gilmar
Sousa, Luciano
Nicolau, Jose C
Giorgeto, Flavio E
Silva, Ricardo P
Maia, Lilia Nigro
Rech, Rafael
Rossi, Paulo RF
Cerqueira, Maria Jose AG
Duda, Norberto
Kalil, Renato
Kormann, Adrian
Abrantes, Jose Antonio M
Pimentel Filho, Pedro
Soggia, Ana Priscila
de Santos, Mayler ON
Neuenschwander, Fernando
Bodanese, Luiz C
Michalaros, Yorghos L
Eliaschewitz, Freddy G
Vidotti, Maria H
Leaes, Paulo E
Botelho, Roberto V
Kaiser, Sergio
Fernandes Manenti, Euler Roberto F
Precoma, Dalton B
Moura Jorge, Jose C
Silva, Pedro GM de B
Silveira, Jose A
Saporito, Wladmir
Marin Neto, Jose A
Feitosa, Gilson S
Ritt, Luiz Eduardo F
de Souza, Juliana A
Costa, Fernando
Souza, Weimar KSB
Reis, Helder JL
Machado, Leandro
Aidar Ayoub, Jose Carlos
Todorov, Georgi V
Nikolov, Fedya P
Velcheva, Elena S
Tzekova, Maria L
Benov, Haralambi O
Petranov, Stanislav L
Tumbev, Haralin S
Shehova-Yankova, Nina S
Markov, Dimitar T
Raev, Dimitar H
Mollov, Mihail N
Kichukov, Kostadin N
Ilieva-Pandeva, Katya A
Ivanova, Raya
Mincheva, Valentina M
Lazov, Petar V
Dimov, Bojidar I
Senaratne, Manohara
Stone, James
Kornder, Jan
Pearce, Stephen
Dion, Danielle
Savard, Daniel
Pesant, Yves
Pandey, Amritanshu
Robinson, Simon
Gosselin, Gilbert
Vizel, Saul
Hoag, Gordon
Bourgeois, Ronald
Morisset, Anne
Sabbah, Eric
Sussex, Bruce
Kouz, Simon
MacDonald, Paul
Diaz, Ariel
Michaud, Nicolas
Fell, David
Leung, Raymond
Vuurmans, Tycho
Lai, Christopher
Nigro, Frank
Davies, Richard
Nogareda, Gustavo
Vijayaraghavan, Ram
Ducas, John
Lepage, Serge
Mehta, Shamir
Cha, James
Dupuis, Robert
Fong, Peter
Rodes-Cabau, Josep
Fadlallah, Hussein
Cleveland, David
Thao, Huynh
Bata, Iqbal
Hameed, Adnan
Pincetti, Cristian
Potthoff, Sergio
Prieto, Juan C
Acevedo, Monica
Aguirre, Arnoldo
Vejar, Margarita
Yanez, Mario
Araneda, Guillermo
Fernandez, Mauricio
Perez, Luis
Varleta, Paola
Florenzano, Fernando
Huidobro, Laura
Raffo, Carlos A
Olivares, Claudia
Nahuelpan, Leonardo
Montecinos, Humberto
Chen, Jiyan
Dong, Yugang
Huang, Weijian
Wang, Jianzhong
Huang, Shi'An
Yao, Zhuhua
Li, Xiang
Cui, Lan
Lin, Wenhua
Sun, Yuemin
Wang, Jingfeng
Li, Jianping
Zhang, Xuelian
Zhu, Hong
Chen, Dandan
Huang, Lan
Dong, Shaohong
Su, Guohai
Xu, Biao
Su, Xi
Cheng, Xiaoshu
Lin, Jinxiu
Zong, Wenxia
Li, Huanming
Feng, Yi
Xu, Dingli
Yang, Xinchun
Ke, Yuannan
Lin, Xuefeng
Zhang, Zheng
Zheng, Zeqi
Luo, Zhurong
Chen, Yundai
Ding, Chunhua
Zheng, Yang
Li, Xiaodong
Peng, Daoquan
Li, Ying
Wei, Meng
Liu, Shaowen
Yu, Yihua
Qu, Baiming
Jiang, Weihong
Zhou, Yujie
Zhao, Xingsheng
Yuan, Zuyi
Guo, Ying
Xu, Xiping
Shi, Xubo
Ge, Junbo
Fu, Guosheng
Bai, Feng
Fang, Weiyi
Shou, Xiling
Yang, Xiangjun
Wang, Jian'An
Sun, Yingxian
Lu, Qinghua
Zhang, Ruiyan
Zhu, Jianhua
Xu, Yizhou
Fan, Zhongcai
Li, Tianchang
Wu, Chun
Jaramillo, Nicolas
Vallejo, Gregorio Sanchez
Botia, Diana C Luna
Lopez, Rodrigo Botero
De Salazar, Dora I Molina
Bonfanti, Alberto J Cadena
Higuera, Juan Diego
Silva, Sandra I Barrera
Lozada, Henry J Garcia
Arroyo, Julian A Coronel
Mendoza, Jose L Accini
Ruiz, Ricardo L Fernandez
Jatin, Fernando G Manzur
Herazo, Aristides Sotomayor
Parada, Jeffrey Castellanos
Triana, Miguel A Urina
Strozzi, Maja
Car, Sinisa
Milicic, Davor
Bencic, Martina Lovric
Pintaric, Hrvoje
Prvulovic, Deiti
Sikic, Jozica
Persic, Viktor
Mileta, Dean
Stambuk, Kresimir
Zdravko, Babic
Tomulic, Vjekoslav
Krstulovic, Stanka Mejic
Starcevic, Boris
Spinar, Jindrich
Horak, David
Stasek, Josef
Alan, David
Machova, Vilma
Linhart, Ales
Novotny, Vojtech
Kaucak, Vladimir
Rokyta, Richard
Naplava, Robert
Coufal, Zdenek
Adamkova, Vera
Podpera, Ivo
Zizka, Jiri
Motovska, Zuzana
Marusincova, Ivana
Svab, Premysl
Ostadal, Petr
Heinc, Petr
Kuchar, Jiri
Povolny, Petr
Matuska, Jiri
Raungaard, Bent
Clemmensen, Peter
Bang, Lia E
May, Ole
Bottcher, Morten
Hove, Jens D
Frost, Lars
Gislason, Gunnar
Larsen, John
Johansen, Peter Betton
Hald, Flemming
Jeppesen, Jorgen
Nielsen, Tonny
Kristensen, Kjeld S
Walichiewicz, Piotr Maria
Lomholdt, Jens D
Klausen, Ib C
Nielsen, Peter Kaiser
Davidsen, Flemming
Videbaek, Lars
Soots, Mai
Vahula, Veiko
Hedman, Anu
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Martsin, Kaja
Kristjan, Arved
Taskinen, Marja-Riitta
Porthan, Kimmo
Airaksinen, Juhani K
Juonala, Markus
Kiviniemi, Tuomas
Vikman, Saila
Posio, Pirjo
Taurio, Jyrki
Huikuri, Heikki
Kaikkonen, Kari
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Ferrari, Emile
Morel, Olivier
Montalescot, Gilles
Barone-Rochette, Gilles
Mansourati, Jacques
Cottin, Yves
Leclercq, Florence
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Delarche, Nicolas
Boccara, Franck
Paganelli, Franck
Clerc, Jerome
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Shaburishvili, Tamaz
Pagava, Zurab
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Khabeishvili, George
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Waltenberger, Johannes
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Pandurangi, Ulhas
Mathur, Rishabh
Kalashetti, Suhas
Bhagwat, Ajit
Raghuraman, Bagirath
Yerra, Shiv Kumar
Bhansali, Prasant
Borse, Rohidas
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Abdullakutty, Jabir
Saathe, Shireesh
Palimkar, Priya
Abdullkutty, Jabir
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Palimkar, Priya
Atar, Shaul
Shechter, Michael
Mosseri, Morris
Arbel, Yaron
Lotan, Chaim
Rosenschein, Uri
Katz, Amos
Henkin, Yaakov
Francis, Adi
Klutstein, Marc
Nikolsky, Eugenia
Turgeman, Yoav
Halabi, Majdi
Kornowski, Ran
Jonas, Michael
Amir, Offer
Rozenman, Yoseph
Fuchs, Shmuel
Hussein, Osamah
Gavish, Dov
Vered, Zvi
Caraco, Yoseph
Elias, Mazen
Tov, Naveh
Lishner, Michael
Elias, Nizar
Piovaccari, Giancarlo
De Pellegrin, Annamaria
Guardigli, Gabriele
Licciardello, Giovanni
Auguadro, Carla
Cuccia, Claudio
Salvioni, Alessandro
Musumeci, Giuseppe
Calabro, Paolo
Novo, Salvatore
Faggiano, Pompilio
De Cesare, Nicoletta B
Berti, Sergio
Cavallini, Claudio
Puccioni, Enrico
Galvani, Marcello
Tespili, Maurizio
Piatti, Piermarco
Palvarini, Michela
De Luca, Giuseppe
Violini, Roberto
De Leo, Alessandro
Filardi, Pasquale Perrone
Ferratini, Maurizio
Ricca, Vittorio
Dai, Kazuoki
Kamiya, Haruo
Ando, Kenji
Takeda, Yoshihiro
Morino, Yoshihiro
Hata, Yoshiki
Kimura, Kazuo
Kishi, Koichi
Michishita, Ichiro
Uehara, Hiroki
Higashikata, Toshinori
Hirayama, Atsushi
Hirooka, Keiji
Sakagami, Satoru
Taguchi, Shuichi
Koike, Akihiro
Fujinaga, Hiroyuki
Koba, Shinji
Kozuma, Ken
Kawasaki, Tomohiro
Ono, Yujiro
Shimizu, Masatoshi
Katsuda, Yousuke
Wada, Atsuyuki
Shinke, Toshiro
Kimura, Takeshi
Ako, Junya
Fujii, Kenshi
Takahashi, Toshiyuki
Sakamoto, Tomohiro
Furukawa, Yutaka
Sugino, Hiroshi
Mano, Toshiaki
Utsu, Noriaki
Ito, Kashima
Haraguchi, Takuya
Ueda, Yasunori
Nishibe, Akira
Fujimoto, Kazuteru
Masutani, Motomaru
Fujimoto, Kazuteru
Yoon, Jung Han
Kim, Sang-Hyun
Park, Hun Sik
Chae, In-Ho
Kim, Moo Hyun
Jeong, Myung Ho
Rha, Seungwoon
Kim, Chongjin
Kim, Hyo-Soo
Hong, Taekjong
Tahk, Seung-Jea
Kim, Youngkwon
Busmane, Arija
Pontaga, Natalija
Strelnieks, Aldis
Mintale, Iveta
Sime, Iveta
Petrulioniene, Zaneta
Kavaliauskiene, Roma
Jurgaitiene, Ruta
Sakalyte, Gintare
Slapikas, Rimvydas
Norkiene, Sigute
Misonis, Nerijus
Kibarskis, Aleksandras
Kubilius, Raimondas
Bojovski, Stojko
Kedev, Sasko
Lozance, Nensi
Kjovkaroski, Aleksandar
Doncovska, Snezana
Ong, Tiong Kiam
Kasim, Sazzli
Maskon, Oteh
Kandasamy, Balachandran
Yusoff, Khalid
Liew, Houng B
Mohamed, Wan Mohd Izani Wan
Garcia Castillo, Armando
Carrillo Calvillo, Jorge
Fajardo Campos, Pedro
Nunez Fragoso, Juan Carlos
Bayram Llamas, Edmundo Alfredo
Alcocer Gamba, Marco Antonio
Carranza Madrigal, Jaime
Gonzalez Salas, Luis Gerardo
Lopez Rosas, Enrique
Gonzalez Diaz, Belinda
Salcido Vazquez, Eduardo
Nacoud Ackar, Alfredo
Llamas Esperon, Guillermo Antonio
Martinez Sanchez, Carlos Rodolfo
Guerrero De Leon, Maria
Suarez Otero, Rodrigo
Fanghanel Salmon, Guillermo
Perez Rios, Jesus Antonio
Garza Ruiz, Jose Angel
Breedveld, Robert W
Hoogslag, Pieter AM
Suryapranata, Harry
Oomen, Antonius
Wiersma, Jacobijne J
Van Der Wal, Ruud MA
Van Huysduynen-Monraats, Pascalle S Hooft
Karalis, Ioannis
Verdel, Gerardus JE
Brueren, Bart RG
Troquay, Roland PTh
Viergever, Eric P
Al-Windy, Nadea YY
Bartels, Gerard L
Cornel, Jan H
Hermans, Walter RM
Herrman, Johannes PR
Bos, Robert J
Groutars, Reginald GEJ
Van Der Zwaan, Coenraad C
Kaplan, Refik
Ronner, Eelko
Groenemeijer, Bjorn E
Bronzwaer, Patrick NA
Liem, Anho AH
Rensing, Bernard JWM
Bokern, Marcel JJA
Nijmeijer, Remco
Hersbach, Ferry MRJ
Willems, Frank F
Gosselink, Antonius TM
Elliott, John
Wilkins, Gerard
Fisher, Raewyn
Scott, Douglas
Hart, Hamish
Stewart, Ralph
Harding, Scott
Ternouth, Ian
Fisher, Nicholas
Aitken, Denise
Anscombe, Russell
Davidson, Laura
Tomala, Tadeusz
Nygard, Ottar
Sparby, Jon Arne
Andersen, Kjell
Gullestad, Lars
Jortveit, Jarle
Munk, Peter S
Singsaas, Erlend Gyllensten
Halvorsen, Sigrun
Hurtig, Ulf
Correa Flores, Roger M
Calderon Ticona, Jorge R
Durand Velasquez, Julio R
Negron Miguel, Sandra A
Sanabria Perez, Enrique S
Carrion Chambilla, Jesus M
Chavez Ayala, Carlos A
Castillo Leon, Reynaldo P
Vargas Gonzales, Rolando J
Hernandez Zuniga, Jose D
Camacho Cosavalente, Luis A
Bravo Mannucci, Jorge E
Heredia Landeo, Javier
Llerena Navarro, Nassip C
Roldan Concha, Yudy M
Rodriguez Chavez, V-ctor E
Anchante Hernandez, Henry A
Zea Nunez, Carlos A
Mogrovejo Ramos, Walter
Ferrolino, Arthur
Sy, Rosa Allyn G
Tirador, Louie
Sy, Rody G
Matiga, Generoso
Coching, Raul Martin
Bernan, Alisa
Rogelio, Gregorio
Morales, Dante D
Tan, Edgar
Sulit, Dennis Jose
Wlodarczak, Adrian
Jaworska, Krystyna
Skonieczny, Grzegorz
Pawlowicz, Lidia
Wojewod, Pawel
Busz-Papiez, Benita
Bednarski, Janusz
Goch, Aleksander
Staneta, Pawel
Dulak, Elzbieta
Budaj, Andrzej
Saminsk, Krzysztof
Krasowski, Wlodzimierz
Sudnik, Wanda
Zurakowski, Aleksander
Skorski, Marcin
Lysek, Roman
Miklaszewicz, Beata
Kubica, Jacek
Lipko, Jan Andrzej
Kostarska-Srokosz, Edyta
Piepiorka, Marek
Drzewiecka, Anna
Sciborski, Ryszard
Stasiewski, Arkadiusz
Blicharski, Tomasz
Bystryk, Leszek
Szpajer, Michal
Korol, Marek
Czerski, Tomasz
Mirek-Bryniarska, Ewa
Gniot, Jacek
Lubinski, Andrzej
Gorny, Jerzy
Franek, Edward
Raczak, Grzegorz
Szwed, Hanna
Monteiro, Pedro
Bastos, Jose Mesquita
Pereira, Helder H
Martins, Dinis
Morais, Joao
Seixo, Filipe
Mendonca, Carlos
Botelho, Ana
Minescu, Bogdan
Istratoaie, Octavian
Tesloianu, Dan N
Dorobantu, Maria
Cristian, Gabriel
Podoleanu, Cristian GC
Constantinescu, Mircea CA
Bengus, Cristina M
Militaru, Constantin
Rosu, Doina
Parepa, Irinel R
Matei, Adrian V
Alexandru, Tom M
Coman, Ioan
Cioranu, Rodica Stanescu
Dimulescu, Doina
Shvarts, Yury
Orlikova, Olga
Kobalava, Zhanna
Barbarash, Olga L
Markov, Valentin
Lyamina, Nadezhda
Gordienko, Alexander
Zrazhevsky, Konstantin
Vishnevsky, Alexander Y
Gurevich, Victor
Stryuk, Raisa
Lomakin, Nikita V
Bokarev, Igor
Shalaev, Sergey
Khaisheva, Larisa
Chizhov, Petr
Viktorova, Inna
Osokina, Natalya
Akatova, Evgenia
Chumakova, Galina
Libov, Igor
Voevoda, Mikhail I
Tretyakova, Tatyana V
Baranov, Evgeny
Shustov, Sergey
Yakushin, Sergey
Gordeev, Ivan
Khasanov, Niiaz
Reshetko, Olga
Sotnikova, Tatiana
Molchanova, Olga
Nikolaev, Konstantin
Gapon, Liudmila
Baranova, Elena
Shogenov, Zaur
Kosmachova, Elena
Karpov, Yuriy
Karpov, Yuri
Povzun, Anton
Egorova, Liudmila
Tyrenko, Vadim V
Ivanov, Igor G
Kanorsky, Sergey
Simic, Dragan
Ivanovic, Nikola
Davidovic, Goran
Tasic, Nebojsa
Asanin, Milika R
Stojic, Stevo
Apostolovic, Svetlana R
Ilic, Stevan
Putnikovic, Biljana
Stankovic, Aleksandar
Arandjelovic, Aleksandra
Radovanovic, Slavica
Ristic, Arsen D
Balinovac, Jovan
Dincic, Dragan V
Seferovic, Petar
Dodic, Slobodan
Dimkovic, Sinisa
Poh, Kian Keong 
ONG HEAN YEE 
Micko, Karol
Nociar, Jan
Pella, Daniel
Fulop, Peter
Hranai, Marian
Palka, Juraj
Mazur, Juraj
Majercak, Ivan
Dzupina, Andrej
Fazekas, Frantisek
Gonsorcik, Jozef
Bugan, Viliam
Selecky, Juraj
Kamensky, Gabriel
Strbova, Jaroslava
Smik, Rudolf
Dukat, Andrej
Olexa, Peter
Zuran, Ivan
Poklukar, Janez
Suligoj, Natasa Cerni
Cevc, Matija
Cyster, Henry P
Ranjith, Naresh
Corbett, Clive
Bayat, Junaid
Makotoko, Ellen Makoali
Kapp, Ilse E
Basson, Matthys M de V
Lottering, Hanlie
Van Zyl, Louis J
Sebastian, Peter J
Pillay, Thayabran
Saaiman, Jan A
Commerford, Patrick J
Cassimjee, Soraya
Ebrahim, Iftikhar O
Sarvan, Mahomed
Mynhardt, Joseph H
Reuter, Helmuth
Moodley, Rajendran
Vida, Manuel
Cequier Fillat, Angel R
Peris, Vicente Bodi
Jimenez, Francisco Fuentes
Marin, Francisco
Cruz Fernandez, Jose M
Gil-Extremera, Blas
Diz, Fernando Worner
Garcia-Dorado, David
Iniguez, Andres
Tunon Fernandez, Jose
Gonzalez-Juanatey, Jose R
Fernandez Portales, Javier
Civeira Murillo, Fernando
Matas Pericas, Laia
Luis Zamorano, Jose
De Mora Martin, Manuel
Bruguera Cortada, Jordi
Alonso Martin, Joaquin J
De Berrazueta Fernandez, Jose R
Diaz Fernandez, Jose Francisco
Garcia Lledo, Jose Alberto
Cosin Sales, Juan
Botas Rodriguez, Javier
Gusi Tragant, Gabriel
Benedicto, Amparo
Gonzalez-Juanatey, Carlos
Camprubi Potau, Mercedes
Plaza Perez, Ignacio
Moris De La Tassa, Cesar
Loma-Osorio Rincon, Pablo
Balaguer Recena, Javier
Escudier, Juan M
Coca Payeras, Antonio
Alonso Orcajo, Norberto
Valdivielso, Pedro
Constantine, Godwin
Haniffa, Ruvaiz
Tissera, Nirmali
Amarasekera, Stanley
Fernando, Nimali
Jayawardena, Jayanthimala
Santharaj, Wijeyasingam
Ekanayaka, Ruvan
Mendis, Sepalika
Senaratne, Vajira
Mayurathan, Gnanamoorthy
Sirisena, Thilak
Rajapaksha, Ajantha
Herath, Jagath I
Amarasena, Naomali
Berglund, Stefan
Rasmanis, Gundars
Witt, Nils
Mourtzinis, Georgios
Nicol, Peter
Hansen, Ole
Romeo, Stefano
Jensen, Steen Agergaard
Torstensson, Ingemar
Ahremark, Ulf
Sundelin, Torbjorn
Moccetti, Tiziano
Muller, Christian
Mach, Francois
Binder, Ronald
Tsai, Wei-Chuan
Ueng, Kwo-Chang
Lai, Wen-Ter
Liu, Ming-En
Hwang, Juey-Jen
Yin, Wei-Hsian
Hsieh, I-Chang
Lin, Wei Hsiang
Kuo, Jen-Yuan
Huang, Tsuei-Yuan
Fang, Chih-Yuan
Kaewsuwanna, Pinij
Soonfuang, Wasant
Jintapakorn, Woravut
Sukonthasarn, Apichard
Wongpraparut, Nattawut
Sastravaha, Krisada
Sansanayudh, Nakarin
Kehasukcharoen, Wirash
Piyayotai, Dilok
Chotnoparatpat, Paiboon
Camsari, Ahmet
Kultursay, Hakan
Mutlu, Bulent
Ersanli, Murat
Demirtas, Mustafa
Kirma, Cevat
Ural, Ertan
Koldas, Lale
Karpenko, Oleksandr
Prokhorov, Alexander
Vakaluyk, Ihor
Myshanych, Halyna
Reshotko, Dmytro
Batushkin, Valeriy
Rudenko, Leonid
Kovalskyi, Ihor
Kushnir, Mykola
Tseluyko, Vira
Mostovoy, Yuriy
Stanislavchuk, Mykola
Kyiak, Yulian
Karpenko, Yuriy
Malynovsky, Yaroslav
Klantsa, Andriy
Kutniy, Oles
Amosova, Ekaterina
Tashchuk, Viktor
Leshchuk, Oleh
Rishko, Mykola
Kopytsya, Mykola
Yagensky, Andriy
Vatutin, Mykola
Bagriy, Andriy
Barna, Olga M
Ushakov, Olexiy
Dzyak, Georgiy
Goloborodko, Borys
Rudenko, Anatolii
Zheleznyy, Volodymyr
Trevelyan, Jasper
Zaman, Azfar
Lee, Kaeng
Moriarty, Andrew
Aggarwal, Rajesh K
Clifford, Piers
Wong, Yuk-Ki
Iqbal, Syed MR
Subkovas, Eduardas
Braganza, Denise
Sarkar, David
Storey, Robert
Griffiths, Huw
Mcclure, Sam
Muthusamy, Rangasamy
Kurian, John
Levy, Terry
Barr, Craig
Kadr, Honer
Gerber, Robert
Simaitis, Audrius
Soran, Handrean
Mathur, Anthony
Brodison, Adrian
Oliver, Richard
Mudawi, Telal
Reynolds, Timothy
Sharman, David
Butler, Rob
Wilkinson, Peter
Lip, Gregory YH
Halcox, Julian
Vardi, Gil
Baldari, Duccio
Brabham, David
Treasure, Charles
Dahl, Charles
Palmer, Bruce
Wiseman, Alan
Khan, Abul
Puri, Sanjeev
Mohart, Ann Elizabeth
Ince, Carlos
Flores, Enrique
Wright, Scott
Cheng, Shi-Chi
Rosenberg, Michael
Rogers, William
Kosinski, Edward
Forgosh, Les
Waltman, Jonathan
Khan, Misal
Shoukfeh, Mohammad
Dagher, Georges
Lieber, Ira
Kumar, Priya
East, Cara
Krichmar, Perry
White, Lindsey
Knickelbine, Thomas
Haldis, Thomas
Gillespie, Eve
Suh, David
Arif, Imran
Akhter, Faiq
Carlson, Eric
D'Urso, Michael
El-Ahdab, Fadi
Nelson, William
Harris, Barry
Cohen, Steven
Carter, Luther
Sabatino, Kenneth
Haddad, Tariq
Malik, Amir
Rao, Sunder
Mulkay, Angel
Jovin, Ion
Klancke, Kim
Malhotra, Vinay
Devarapalli, Sai K
Koren, Michael
Chandna, Harish
Dodds, George
Janik, Matthew
Moran, Joseph
Sumner, Andrew
Kobayashi, John
Davis, William
Yazdani, Shahram
Pasquini, John
Thakkar, Maitreya
Vedere, Amarnath
Leimbach, Wayne
Rider, James
Singh, Narendra
Shah, Anil V
Janosik, Denise
Pepine, Carl
Berman, Brett
Gelormini, Joseph
Daniels, Christopher
Keating, Friederike
Kondo, Nicholas I
Shetty, Sanjay
Waider, Winfried
Takata, Theodore
Abu-Fadel, Mazen
Shah, Vipul
Aggarwal, Rahul
Izzo, Mark
Kumar, Anil
Hattler, Brack
Link, Chad
Bortnick, Anna
Kinzfogl, George
Ghitis, Arnold
Larry, John
Teufel, Edward
Kuhlman, Peter
Mclaurin, Brent
Zhang, Wenwu
Thew, Stephen
Abbas, Jalal
White, Matthew
Ranadive, Nandkishore
Gring, Christian
Henderson, David
Schuchard, Timothy
Farhat, Naim
Kline, Geoffrey
Mahal, Sharan
Whitaker, Jack
Speirs, Shawn
Andersen, Rolf
Daboul, Nizar
Horwitz, Phillip
Ponce, George
Jafar, Zubair
Mcgarvey, Joseph
Panchal, Vipul
Voyce, Stephen
Blok, Thomas
Sheldon, William
Azizad, Masoud M
Schmalfuss, Carsten
Picone, Mark
Herzog, William
Lindsey, Jason
Nowins, Rosemary
Lepor, Norman
El Shahawy, Mahfouz
Weintraub, Howard
Irimpen, Anand
May, Wade
Galski, Thomas
Chu, Alan
Mody, Freny
Hodes, Zachary
Rose, Gregory
Fairlamb, James
Lambert, Charles
Raisinghani, Ajit
Abbate, Antonio
King, Marilyn
Carey, Charles
Gerber, Jaime
Younis, Liwa
Park, Hyeun Tom
Vidovich, Mladen
Knutson, Thomas
Friedman, Dennis
Chaleff, Fred
Loussararian, Arthur
Rozeman, Phillip
Kimmelstiel, Carey
Silver, Kevin
Foster, Malcolm
Tonnessen, Glen
Amlani, Mohamadali
Wali, Andreas
Malozzi, Christopher
Wattanakit, Keattiyoat
O'Donnell, Philip J
Singal, Dinesh
Jaffrani, Naseem
Banuru, Sridhar
Fisher, Daniel
Xenakis, Mark
Perlmutter, Neal
Bhagwat, Ravi
Strader, James
Akyea-Djamson, Ayim
Labroo, Ajay
Lee, Kwan
Marais, H John
Claxton, Edmund
Berk, Martin
Rossi, Peter
Joshi, Parag
Khaira, Ajit S
Kumkumian, Greg
Lupovitch, Steven
Purow, Joshua
Welka, Stephen
Hoffman, David
Fischer, Stuart
Soroka, Eugene
Eagerton, Donald
Pancholy, Samir
Ray, Michael
Farrar, Michael
Pollock, Stewart
French, William J
Diamantis, Steve
Gimple, Lawrence
Neustel, Mark
Schwartz, Steven
Pereira, Edward
Spriggs, Douglas
Strain, Janet
Vo, Anthony
Chane, Majed
Hall, Jason
Vijay, Nampalli
Lotun, Kapildeo
Lester, F Martin
Nahhas, Ahed
Pope, Theodore
Nager, Paul
Vohra, Rakesh
Bashir, Riyaz
Ahmed, Hinan
Berlowitz, Michael
Fishberg, Robert
Barrucco, Robert
Yang, Eric
Radin, Michael
Sporn, Daniel
Eisenberg, Steven
Landzberg, Joel
Mcgough, Martin
Turk, Samir
Schwartz, Michael
Sundram, P Sandy
Jain, Diwakar
Zainea, Mark
Bayron, Carlos
Karlsberg, Ronald
Lui, Henry
Keen, William
Westerhausen, Donald
Khurana, Sandeep
Agarwal, Himanshu
Birchem, Jessica
Penny, William
Chang, Mark
Murphy, Sherrill
Murphy, Sherrill
Schifferdecker, Branislav
Gilbert, John M
Chalavarya, Gopal
Eaton, Charles
Schmedtje, John F
Christenson, Stuart
Denham, Douglas
Macdonell, Alexander
Gibson, Paul
Rahman, Aref
Al Joundi, Tammam
Conrad, Gary
Kotha, Purushotham
Love, Michael
Giesler, Gregory
Rubenstein, Howard
Akright, Laura
Krawczyk, Justine
Wells, Terry
Welker, James
Foster, Robert
Gilmore, Richard
Anderson, Jay
Jacoby, Douglas
Harris, Bill
Gardner, Geraldine
Dandillaya, Ramprasad
Vora, Kishor
Kostis, John
Hunter, John
Laxson, David
Ball, Eric
Camp, Alan
Lopes, Renato
Egydio, Flavia
Kawakami, Anelise
Oliveira, Janaina
Wozniak, Julianna
Matthews, Alexander
Ratky, Caroline
Valiris, Janine
Berdan, Lisa
Hepditch, Anita
Quintero, Kirby
Rorick, Tyrus
Westbrook, Melissa
Pascual, Andrea
Rovito, Carla
Bezault, Madeleine
Drouet, Elodie
Simon, Tabassome
Alsweiler, Caroline
Luyten, Anne
Aylward, Phil
Butters, Julie
Griffith, Liddy
Shaw, Michelle
Hagstrom, Emil
Grunberg, Lena
Islam, Shahidul
Bregeault, Marie-France
Bougon, Nathalie
Faustino, Douglas
Fontecave, Sylvie
Murphy, Judith
Tamby, Jean-Francois
Verrier, Melanie
Agnetti, Veronique
Andersen, Dorthe
Badreddine, Emmy
Bekkouche, Mhamed
Bouancheau, Cecile
Brigui, Imane
Brocklehurst, Maddy
Cianciarulo, Joseph
Devaul, Dawn
Domokos, Szilvia
Gache, Cecile
Gobillot, Caroline
Guillou, Severine
Healy, Jan
Heath, Megan
Jaiwal, Gayatri
Javierre, Carine
Labeirie, Julien
Monier, Myriam
Morales, Ulises
Mrabti, Asmaa
Mthombeni, Bicky
Okan, Betim
Smith, Lucile
Sheller, Jennifer
Sopena, Sebastien
Pellan, Valerie
Benbernou, Fadela
Bengrait, Nafissa
Lamoureux, Maud
Kralova, Katarina
Scemama, Michel
Bejuit, Raphael
Coulange, Anthony
Berthou, Christelle
Repincay, Jerome
Lorenzato, Christelle
Etienne, Alexis
Gouet, Valerie
Loizeau, Virginie
Normand, Mickael
Ourliac, Anne
Rondel, Christelle
Adamo, Antony
Beltran, Pascale
Barraud, Pauline
Dubois-Gache, Helene
Halle, Benjamin
Metwally, Lamia
Mourgues, Maxime
Sotty, Marc
Vincendet, Marion
Cotruta, Raluca
Zhu, Chengyue
Fournie-Lloret, Dominique
Morrello, Christine
Perthuis, Aurelie
Picault, Patrick
Zobouyan, Isabelle
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
Cardiovascular System & Cardiology
acute coronary syndrome
alirocumab
cholesterol
mortality
PCSK9 protein
MONOCLONAL-ANTIBODY
REDUCING LIPIDS
EFFICACY
SAFETY
EVOLOCUMAB
PCSK9
Issue Date: 9-Jul-2019
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: Steg, Philippe Gabriel, Szarek, Michael, Bhatt, Deepak L, Bittner, Vera A, Bregeault, Marie-France, Dalby, Anthony J, Diaz, Rafael, Edelberg, Jay M, Goodman, Shaun G, Hanotin, Corinne, Harrington, Robert A, Jukema, J Wouter, Lecorps, Guillaume, Mahaffey, Kenneth W, Moryusef, Angele, Ostadal, Petr, Parkhomenko, Alexander, Pordy, Robert, Roe, Matthew T, Tricoci, Pierluigi, Vogel, Robert, White, Harvey D, Zeiher, Andreas M, Schwartz, Gregory G, Sasiela, William J, Tamby, Jean-Francois, Aylward, Philip E, Drexel, Heinz, Sinnaeve, Peter, Dilic, Mirza, Gotcheva, Nina N, Goodman, Shaun G, Prieto, Juan-Carlos, Yong, Huo, Lopez-Jaramillo, Patricio, Pecin, Ivan, Reiner, Zeljko, Ostadal, Petr, Poulsen, Steen Hvitfeldt, Viigimaa, Margus, Nieminen, Markku S, Danchin, Nicolas, Chumburidze, Vakhtang, Marx, Nikolaus, Liberopoulos, Evangelos, Valdovinos, Pablo Carlos Montenegro, Tse, Hung-Fat, Kiss, Robert Gabor, Xavier, Denis, Zahger, Doron, Valgimigli, Marco, Kimura, Takeshi, Kim, Hyo Soo, Kim, Sang-Hyun, Kedev, Sasko, Erglis, Andrejs, Laucevicius, Aleksandras, Yusoff, Khalid, Lopez, Ramos, Ramos Lopez, Gabriel Arturo, Alings, Marco, Halvorsen, Sigrun, Correa Flores, Roger M, Sy, Rody G, Budaj, Andrzej, Morais, Joao, Dorobantu, Maria, Karpov, Yuri, Ristic, Arsen D, Chua, Terrance, Murin, Jan, Fras, Zlatko, Dalby, Anthony J, Tunon, Jose, de Silva, H Asita, Hagstrom, Emil, Muller, Christian, Chiang, Chern-En, Sritara, Piyamitr, Guneri, Sema, Parkhomenko, Alexander, Ray, Kausik K, Moriarty, Patrick M, Roe, Matthew T, Chaitman, Bernard, Kelsey, Sheryl F, Olsson, Anders G, Rouleau, Jean-Lucien, Simoons, Maarten L, Alexander, Karen, Meloni, Chiara, Rosenson, Robert, Sijbrands, Eric JG, Alexander, John H, Armaganijan, Luciana, Bagai, Akshay, Bahit, Maria Cecilia, Brennan, J Matthew, Clifton, Shaun, DeVore, Adam D, Deloatch, Shalonda, Dickey, Sheila, Dombrowski, Keith, Ducrocq, Gregory, Eapen, Zubin, Endsley, Patricia, Eppinger, Arleen, Harrison, Robert W, Hess, Connie Ng, Hlatky, Mark A, Jordan, Joseph Dedrick, Knowles, Joshua W, Kolls, Bradley J, Kong, David F, Leonardi, Sergio, Lillis, Linda, Maron, David J, Marcus, Jill, Mathews, Robin, Mehta, Rajendra H, Mentz, Robert J, Moreira, Humberto Graner, Patel, Chetan B, Pereira, Sabrina Bernardez, Perkins, Lynn, Povsic, Thomas J, Puymirat, Etienne, Jones, William Schuyler, Shah, Bimal R, Sherwood, Matthew W, Stringfellow, Kenya, Sujjavanich, Darin, Toma, Mustafa, Van Diepen, Sean FP, Wilson, Matthew D, Yan, Andrew Tze-Kay, Lopes, Renato D, Trotter, Charlene, Schiavi, Lilia B, Garrido, Marcelo, Alvarisqueta, Andres F, Sassone, Sonia A, Bordonava, Anselmo P, Alves De Lima, Alberto E, Schmidberg, Jorge M, Duronto, Ernesto A, Caruso, Orlando C, Novaretto, Leonardo P, Angel Hominal, Miguel, Montana, Oscar R, Caccavo, Alberto, Gomez Vilamajo, Oscar A, Lorenzatti, Alberto J, Cartasegna, Luis R, Paterlini, Gustavo A, Mackinnon, Ignacio J, Caime, Guillermo D, Amuchastegui, Marcos, Salomone, Rodolfo, Codutti, Oscar R, Jure, Horacio O, Bono, Julio OE, Hrabar, Adrian D, Vallejos, Julio A, Ahuad Guerrero, Rodolfo A, Novoa, Federico, Patocchi, Cristian A, Zaidman, Cesar J, Giuliano, Maria E, Dran, Ricardo D, Vico, Marisa L, Carnero, Gabriela S, Guzman, Pablo N, Medrano Allende, Juan C, Garcia Brasca, Daniela F, Bustamante Labarta, Miguel H, Nani, Sebastian, Blumberg, Eduardo DS, Colombo, Hugo R, Liberman, Alberto, Luciardi, Hector L, Waisman, Gabriel D, Berli, Mario A, Duran, Ruben O Garcia, Cestari, Horacio G, Luquez, Hugo A, Giordano, Jorge A, Saavedra, Silvia S, Zapata, Gerardo, Costamagna, Osvaldo, Llois, Susana, Waites, Jonathon H, Collins, Nicholas, Soward, Allan, Aylward, Philip E, Hii, Chris LS, Shaw, James, Arstall, Margaret A, Horowitz, John, Rogers, James F, Colquhoun, David, Oqueli Flores, Romulo E, Roberts-Thomson, Philip, Raffel, Owen, Lehman, Sam J, Aroney, Constantine, Coverdale, Steven GM, Garrahy, Paul J, Starmer, Gregory, Sader, Mark, Carroll, Patrick A, Dick, Ronald, Zweiker, Robert, Hoppe, Uta, Huber, Kurt, Berger, Rudolf, Weidinger, Franz, Faes, Dirk, Hermans, Kurt, Pirenne, Bruno, Leone, Attilio, Hoffer, Etienne, Vrolix, Mathias CM, De Wolf, Luc, Wollaert, Bart, Castadot, Marc, Dujardin, Karl, Beauloye, Christophe, Vervoort, Geert, Striekwold, Harry, Convens, Carl, Roosen, John, Barbato, Emanuele, Claeys, Marc, Cools, Frank, Terzic, Ibrahim, Barakovic, Fahir, Midzic, Zlatko, Pojskic, Belma, Fazlibegovic, Emir, Durak-Nalbantic, Azra, Vulic, Dusko, Muslibegovic, Adis, Goronja, Boris, Reis, Gilmar, Sousa, Luciano, Nicolau, Jose C, Giorgeto, Flavio E, Silva, Ricardo P, Maia, Lilia Nigro, Rech, Rafael, Rossi, Paulo RF, Cerqueira, Maria Jose AG, Duda, Norberto, Kalil, Renato, Kormann, Adrian, Abrantes, Jose Antonio M, Pimentel Filho, Pedro, Soggia, Ana Priscila, de Santos, Mayler ON, Neuenschwander, Fernando, Bodanese, Luiz C, Michalaros, Yorghos L, Eliaschewitz, Freddy G, Vidotti, Maria H, Leaes, Paulo E, Botelho, Roberto V, Kaiser, Sergio, Fernandes Manenti, Euler Roberto F, Precoma, Dalton B, Moura Jorge, Jose C, Silva, Pedro GM de B, Silveira, Jose A, Saporito, Wladmir, Marin Neto, Jose A, Feitosa, Gilson S, Ritt, Luiz Eduardo F, de Souza, Juliana A, Costa, Fernando, Souza, Weimar KSB, Reis, Helder JL, Machado, Leandro, Aidar Ayoub, Jose Carlos, Todorov, Georgi V, Nikolov, Fedya P, Velcheva, Elena S, Tzekova, Maria L, Benov, Haralambi O, Petranov, Stanislav L, Tumbev, Haralin S, Shehova-Yankova, Nina S, Markov, Dimitar T, Raev, Dimitar H, Mollov, Mihail N, Kichukov, Kostadin N, Ilieva-Pandeva, Katya A, Ivanova, Raya, Mincheva, Valentina M, Lazov, Petar V, Dimov, Bojidar I, Senaratne, Manohara, Stone, James, Kornder, Jan, Pearce, Stephen, Dion, Danielle, Savard, Daniel, Pesant, Yves, Pandey, Amritanshu, Robinson, Simon, Gosselin, Gilbert, Vizel, Saul, Hoag, Gordon, Bourgeois, Ronald, Morisset, Anne, Sabbah, Eric, Sussex, Bruce, Kouz, Simon, MacDonald, Paul, Diaz, Ariel, Michaud, Nicolas, Fell, David, Leung, Raymond, Vuurmans, Tycho, Lai, 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Zhurong, Chen, Yundai, Ding, Chunhua, Zheng, Yang, Li, Xiaodong, Peng, Daoquan, Li, Ying, Wei, Meng, Liu, Shaowen, Yu, Yihua, Qu, Baiming, Jiang, Weihong, Zhou, Yujie, Zhao, Xingsheng, Yuan, Zuyi, Guo, Ying, Xu, Xiping, Shi, Xubo, Ge, Junbo, Fu, Guosheng, Bai, Feng, Fang, Weiyi, Shou, Xiling, Yang, Xiangjun, Wang, Jian'An, Sun, Yingxian, Lu, Qinghua, Zhang, Ruiyan, Zhu, Jianhua, Xu, Yizhou, Fan, Zhongcai, Li, Tianchang, Wu, Chun, Jaramillo, Nicolas, Vallejo, Gregorio Sanchez, Botia, Diana C Luna, Lopez, Rodrigo Botero, De Salazar, Dora I Molina, Bonfanti, Alberto J Cadena, Higuera, Juan Diego, Silva, Sandra I Barrera, Lozada, Henry J Garcia, Arroyo, Julian A Coronel, Mendoza, Jose L Accini, Ruiz, Ricardo L Fernandez, Jatin, Fernando G Manzur, Herazo, Aristides Sotomayor, Parada, Jeffrey Castellanos, Triana, Miguel A Urina, Strozzi, Maja, Car, Sinisa, Milicic, Davor, Bencic, Martina Lovric, Pintaric, Hrvoje, Prvulovic, Deiti, Sikic, Jozica, Persic, Viktor, Mileta, Dean, Stambuk, 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Claxton, Edmund, Berk, Martin, Rossi, Peter, Joshi, Parag, Khaira, Ajit S, Kumkumian, Greg, Lupovitch, Steven, Purow, Joshua, Welka, Stephen, Hoffman, David, Fischer, Stuart, Soroka, Eugene, Eagerton, Donald, Pancholy, Samir, Ray, Michael, Farrar, Michael, Pollock, Stewart, French, William J, Diamantis, Steve, Gimple, Lawrence, Neustel, Mark, Schwartz, Steven, Pereira, Edward, Spriggs, Douglas, Strain, Janet, Vo, Anthony, Chane, Majed, Hall, Jason, Vijay, Nampalli, Lotun, Kapildeo, Lester, F Martin, Nahhas, Ahed, Pope, Theodore, Nager, Paul, Vohra, Rakesh, Bashir, Riyaz, Ahmed, Hinan, Berlowitz, Michael, Fishberg, Robert, Barrucco, Robert, Yang, Eric, Radin, Michael, Sporn, Daniel, Eisenberg, Steven, Landzberg, Joel, Mcgough, Martin, Turk, Samir, Schwartz, Michael, Sundram, P Sandy, Jain, Diwakar, Zainea, Mark, Bayron, Carlos, Karlsberg, Ronald, Lui, Henry, Keen, William, Westerhausen, Donald, Khurana, Sandeep, Agarwal, Himanshu, Birchem, Jessica, Penny, William, Chang, Mark, Murphy, Sherrill, Murphy, Sherrill, Schifferdecker, Branislav, Gilbert, John M, Chalavarya, Gopal, Eaton, Charles, Schmedtje, John F, Christenson, Stuart, Denham, Douglas, Macdonell, Alexander, Gibson, Paul, Rahman, Aref, Al Joundi, Tammam, Conrad, Gary, Kotha, Purushotham, Love, Michael, Giesler, Gregory, Rubenstein, Howard, Akright, Laura, Krawczyk, Justine, Wells, Terry, Welker, James, Foster, Robert, Gilmore, Richard, Anderson, Jay, Jacoby, Douglas, Harris, Bill, Gardner, Geraldine, Dandillaya, Ramprasad, Vora, Kishor, Kostis, John, Hunter, John, Laxson, David, Ball, Eric, Camp, Alan, Lopes, Renato, Egydio, Flavia, Kawakami, Anelise, Oliveira, Janaina, Wozniak, Julianna, Matthews, Alexander, Ratky, Caroline, Valiris, Janine, Berdan, Lisa, Hepditch, Anita, Quintero, Kirby, Rorick, Tyrus, Westbrook, Melissa, Pascual, Andrea, Rovito, Carla, Bezault, Madeleine, Drouet, Elodie, Simon, Tabassome, Alsweiler, Caroline, Luyten, Anne, Aylward, Phil, Butters, Julie, Griffith, Liddy, Shaw, Michelle, Hagstrom, Emil, Grunberg, Lena, Islam, Shahidul, Bregeault, Marie-France, Bougon, Nathalie, Faustino, Douglas, Fontecave, Sylvie, Murphy, Judith, Tamby, Jean-Francois, Verrier, Melanie, Agnetti, Veronique, Andersen, Dorthe, Badreddine, Emmy, Bekkouche, Mhamed, Bouancheau, Cecile, Brigui, Imane, Brocklehurst, Maddy, Cianciarulo, Joseph, Devaul, Dawn, Domokos, Szilvia, Gache, Cecile, Gobillot, Caroline, Guillou, Severine, Healy, Jan, Heath, Megan, Jaiwal, Gayatri, Javierre, Carine, Labeirie, Julien, Monier, Myriam, Morales, Ulises, Mrabti, Asmaa, Mthombeni, Bicky, Okan, Betim, Smith, Lucile, Sheller, Jennifer, Sopena, Sebastien, Pellan, Valerie, Benbernou, Fadela, Bengrait, Nafissa, Lamoureux, Maud, Kralova, Katarina, Scemama, Michel, Bejuit, Raphael, Coulange, Anthony, Berthou, Christelle, Repincay, Jerome, Lorenzato, Christelle, Etienne, Alexis, Gouet, Valerie, Loizeau, Virginie, Normand, Mickael, Ourliac, Anne, Rondel, Christelle, Adamo, Antony, Beltran, Pascale, Barraud, Pauline, Dubois-Gache, Helene, Halle, Benjamin, Metwally, Lamia, Mourgues, Maxime, Sotty, Marc, Vincendet, Marion, Cotruta, Raluca, Zhu, Chengyue, Fournie-Lloret, Dominique, Morrello, Christine, Perthuis, Aurelie, Picault, Patrick, Zobouyan, Isabelle (2019-07-09). Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial. CIRCULATION 140 (2) : 103-112. ScholarBank@NUS Repository. https://doi.org/10.1161/CIRCULATIONAHA.118.038840
Abstract: BACKGROUND: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. METHODS: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. RESULTS: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths ( P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events ( P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). CONCLUSIONS: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01663402.
Source Title: CIRCULATION
URI: https://scholarbank.nus.edu.sg/handle/10635/208798
ISSN: 0009-7322
1524-4539
DOI: 10.1161/CIRCULATIONAHA.118.038840
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