Please use this identifier to cite or link to this item: https://doi.org/10.3389/fcvm.2021.664431
Title: Age- and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians
Authors: Leng, Shuang 
Guo, Jiajun
Tan, Ru-San
Chai, Ping 
Teo, Lynette 
Fortier, Marielle
Gong, Chao
Zhao, Xiaodan 
Ong, Ching Ching 
Allen, John C 
Ruan, Wen 
Koh, Angela S
Tan, Teng Hong 
Yip, James W
Tan, Ju Le
Chen, Yucheng
Zhong, Liang 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
cardiovascular magnetic resonance
feature tracking
right ventricular function
right atrial function
age
sex
POPULATION
VOLUME
STRAIN
VALUES
HEART
SIZE
Issue Date: 4-Jun-2021
Publisher: FRONTIERS MEDIA SA
Citation: Leng, Shuang, Guo, Jiajun, Tan, Ru-San, Chai, Ping, Teo, Lynette, Fortier, Marielle, Gong, Chao, Zhao, Xiaodan, Ong, Ching Ching, Allen, John C, Ruan, Wen, Koh, Angela S, Tan, Teng Hong, Yip, James W, Tan, Ju Le, Chen, Yucheng, Zhong, Liang (2021-06-04). Age- and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians. FRONTIERS IN CARDIOVASCULAR MEDICINE 8. ScholarBank@NUS Repository. https://doi.org/10.3389/fcvm.2021.664431
Abstract: Cardiovascular magnetic resonance (CMR) is the reference standard for non-invasive assessment of right-sided heart function. Recent advances in CMR post-processing facilitate quantification of tricuspid annular (TA) dynamics and longitudinal strains of the right ventricle (RV) and right atrium (RA). We aimed to determine age- and sex-specific changes in CMR-derived TA dynamics, and RV and RA functional parameters in healthy Asian adults. We studied 360 healthy subjects aged 21-79 years, with 30 men and 30 women in each of the six age groups. Functional parameters of RV and RA were measured on standard four-chamber cine CMR using fast feature tracking: (1) TA peak velocities (systolic velocity S', early diastolic velocity E', late diastolic velocity A') and TA plane systolic excursion (TAPSE); (2) RV global longitudinal strain (GLS) and strain rates; and (3) RA phasic longitudinal strains and strain rates. S' and TAPSE exhibited negative correlations with age. RV GLS was significantly higher in females than in males but not associated with age in both sexes. Females had similar E', lower A', and higher E'/A' ratios compared to males. Positive associations of E' and E'/A', and negative association of A' with age were observed in both sexes. Females had higher RA reservoir and conduit strains compared to males. There were significantly negative and positive associations between RA conduit and booster strains, respectively, with age. Age- and sex-specific reference ranges were established, and associations revealed, for fast CMR feature tracking parameters of right heart function in a large normal Asian population.
Source Title: FRONTIERS IN CARDIOVASCULAR MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/208556
ISSN: 2297055X
DOI: 10.3389/fcvm.2021.664431
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