Please use this identifier to cite or link to this item: https://doi.org/10.1158/1055-9965.EPI-20-0924
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dc.titleBreast cancer risk factors and survival by tumor subtype: Pooled analyses from the breast cancer association consortium
dc.contributor.authorMorra, A
dc.contributor.authorJung, AY
dc.contributor.authorBehrens, S
dc.contributor.authorKeeman, R
dc.contributor.authorAhearn, TU
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorAugustinsson, A
dc.contributor.authorAuvinen, PK
dc.contributor.authorBeane Freeman, LE
dc.contributor.authorBecher, H
dc.contributor.authorBeckmann, MW
dc.contributor.authorBlomqvist, C
dc.contributor.authorBojesen, SE
dc.contributor.authorBolla, MK
dc.contributor.authorBrenner, H
dc.contributor.authorBriceno, I
dc.contributor.authorBrucker, SY
dc.contributor.authorCamp, NJ
dc.contributor.authorCampa, D
dc.contributor.authorCanzian, F
dc.contributor.authorCastelao, JE
dc.contributor.authorChanock, SJ
dc.contributor.authorChoi, JY
dc.contributor.authorClarke, CL
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDork, T
dc.contributor.authorDunning, AM
dc.contributor.authorDwek, M
dc.contributor.authorEaston, DF
dc.contributor.authorEccles, DM
dc.contributor.authorEgan, KM
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFlyger, H
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGapstur, SM
dc.contributor.authorGarcia-Saenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGrip, M
dc.contributor.authorGuenel, P
dc.contributor.authorHaiman, CA
dc.contributor.authorHakansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHan, SN
dc.contributor.authorHart, SN
dc.contributor.authorHartman, M
dc.contributor.authorHeyworth, JS
dc.contributor.authorHoppe, R
dc.contributor.authorHopper, JL
dc.contributor.authorHunter, DJ
dc.contributor.authorIto, H
dc.contributor.authorJager, A
dc.contributor.authorJakimovska, M
dc.contributor.authorJakubowska, A
dc.contributor.authorJanni, W
dc.contributor.authorKaaks, R
dc.contributor.authorKang, D
dc.contributor.authorKapoor, PM
dc.contributor.authorKitahara, CM
dc.contributor.authorKoutros, S
dc.contributor.authorKraft, P
dc.contributor.authorKristensen, VN
dc.contributor.authorLacey, JV
dc.contributor.authorLambrechts, D
dc.contributor.authorLe Marchand, L
dc.contributor.authorLi, J
dc.contributor.authorLindblom, A
dc.contributor.authorLubi-Nski, J
dc.contributor.authorLush, M
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorMargolin, S
dc.contributor.authorMariapun, S
dc.contributor.authorMatsuo, K
dc.contributor.authorMavroudis, D
dc.contributor.authorMilne, RL
dc.contributor.authorMuranen, TA
dc.contributor.authorNewman, WG
dc.contributor.authorNoh, DY
dc.contributor.authorNordestgaard, BG
dc.contributor.authorObi, N
dc.contributor.authorOlshan, AF
dc.contributor.authorOlsson, H
dc.contributor.authorPark-Simon, TW
dc.contributor.authorPetridis, C
dc.contributor.authorPharoah, PDP
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPresneau, N
dc.contributor.authorRashid, MU
dc.contributor.authorRennert, G
dc.contributor.authorRennert, HS
dc.contributor.authorRhenius, V
dc.contributor.authorRomero, A
dc.contributor.authorSaloustros, E
dc.date.accessioned2021-11-26T14:21:21Z
dc.date.available2021-11-26T14:21:21Z
dc.date.issued2021-04-01
dc.identifier.citationMorra, A, Jung, AY, Behrens, S, Keeman, R, Ahearn, TU, Anton-Culver, H, Arndt, V, Augustinsson, A, Auvinen, PK, Beane Freeman, LE, Becher, H, Beckmann, MW, Blomqvist, C, Bojesen, SE, Bolla, MK, Brenner, H, Briceno, I, Brucker, SY, Camp, NJ, Campa, D, Canzian, F, Castelao, JE, Chanock, SJ, Choi, JY, Clarke, CL, Couch, FJ, Cox, A, Cross, SS, Czene, K, Dork, T, Dunning, AM, Dwek, M, Easton, DF, Eccles, DM, Egan, KM, Evans, DG, Fasching, PA, Flyger, H, Gago-Dominguez, M, Gapstur, SM, Garcia-Saenz, JA, Gaudet, MM, Giles, GG, Grip, M, Guenel, P, Haiman, CA, Hakansson, N, Hall, P, Hamann, U, Han, SN, Hart, SN, Hartman, M, Heyworth, JS, Hoppe, R, Hopper, JL, Hunter, DJ, Ito, H, Jager, A, Jakimovska, M, Jakubowska, A, Janni, W, Kaaks, R, Kang, D, Kapoor, PM, Kitahara, CM, Koutros, S, Kraft, P, Kristensen, VN, Lacey, JV, Lambrechts, D, Le Marchand, L, Li, J, Lindblom, A, Lubi-Nski, J, Lush, M, Mannermaa, A, Manoochehri, M, Margolin, S, Mariapun, S, Matsuo, K, Mavroudis, D, Milne, RL, Muranen, TA, Newman, WG, Noh, DY, Nordestgaard, BG, Obi, N, Olshan, AF, Olsson, H, Park-Simon, TW, Petridis, C, Pharoah, PDP, Plaseska-Karanfilska, D, Presneau, N, Rashid, MU, Rennert, G, Rennert, HS, Rhenius, V, Romero, A, Saloustros, E (2021-04-01). Breast cancer risk factors and survival by tumor subtype: Pooled analyses from the breast cancer association consortium. Cancer Epidemiology Biomarkers and Prevention 30 (4) : 623-642. ScholarBank@NUS Repository. https://doi.org/10.1158/1055-9965.EPI-20-0924
dc.identifier.issn10559965
dc.identifier.issn15387755
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/208337
dc.description.abstractBackground: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. Methods: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer. specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype. Results: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5.25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72-0.86)]; >0.<5 years versus ≥10 years since last full-term birth [1.31 (1.11-1.55)]; ever versus never use of oral contraceptives [0.91 (0.87-0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen.progestin therapy [0.61 (0.54.0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02-1.21) for current versus never smoking. Conclusions: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype. Impact: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.
dc.publisherAmerican Association for Cancer Research (AACR)
dc.sourceElements
dc.subjectABCTB Investigators
dc.subjectNBCS Collaborators
dc.typeArticle
dc.date.updated2021-11-25T17:03:39Z
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.description.doi10.1158/1055-9965.EPI-20-0924
dc.description.sourcetitleCancer Epidemiology Biomarkers and Prevention
dc.description.volume30
dc.description.issue4
dc.description.page623-642
dc.published.statePublished
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