Please use this identifier to cite or link to this item: https://doi.org/10.1136/bmjopen-2017-020512
Title: Health-related quality of life in Asian patients with breast cancer: a systematic review
Authors: Ho, Peh Joo
Gernaat, Sofie AM
Hartman, Mikael 
Verkooijen, Helena M
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
CHINESE WOMEN
UNMET NEEDS
FACT-B
EUROPEAN-ORGANIZATION
CONSERVATION THERAPY
MENOPAUSAL SYMPTOMS
SOCIAL SUPPORT
KOREAN VERSION
MEDIATING ROLE
EORTC QLQ-C30
Issue Date: 1-Apr-2018
Publisher: BMJ PUBLISHING GROUP
Citation: Ho, Peh Joo, Gernaat, Sofie AM, Hartman, Mikael, Verkooijen, Helena M (2018-04-01). Health-related quality of life in Asian patients with breast cancer: a systematic review. BMJ OPEN 8 (4). ScholarBank@NUS Repository. https://doi.org/10.1136/bmjopen-2017-020512
Abstract: Objective To summarise the evidence on determinants of health-related quality of life (HRQL) in Asian patients with breast cancer. Design Systematic review conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations and registered with PROSPERO (CRD42015032468). Methods According to the PRISMA guidelines, databases of MEDLINE (PubMed), Embase and PsycINFO were systematically searched using the following terms and synonyms: breast cancer, quality of life and Asia. Articles reporting on HRQL using EORTC-QLQ-C30, EORTC-QLQ-BR23, FACT-G and FACT-B questionnaires in Asian patients with breast cancer were eligible for inclusion. The methodological quality of each article was assessed using the quality assessment scale for cross-sectional studies or the Newcastle-Ottawa Quality Assessment Scale for cohort studies. Results Fifty-seven articles were selected for this qualitative synthesis, of which 43 (75%) were cross-sectional and 14 (25%) were longitudinal studies. Over 75 different determinants of HRQL were studied with either the EORTC or FACT questionnaires. Patients with comorbidities, treated with chemotherapy, with less social support and with more unmet needs have poorer HRQL. HRQL improves over time. Discordant results in studies were found in the association of age, marital status, household income, type of surgery, radiotherapy and hormone therapy and unmet sexuality needs with poor global health status or overall well-being. Conclusions In Asia, patients with breast cancer, in particular those with other comorbidities and those treated with chemotherapy, with less social support and with more unmet needs, have poorer HRQL. Appropriate social support and meeting the needs of patients may improve patients' HRQL.
Source Title: BMJ OPEN
URI: https://scholarbank.nus.edu.sg/handle/10635/208272
ISSN: 20446055
DOI: 10.1136/bmjopen-2017-020512
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