Please use this identifier to cite or link to this item: https://doi.org/10.1002/mgg3.707
Title: The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium
Authors: Ugai, Tomotaka
Milne, Roger L
Ito, Hidemi
Aronson, Kristan J
Bolla, Manjeet K
Chan, Tsun
Chan, Ching W
Choi, Ji-Yeob
Conroy, Don M
Dennis, Joe
Dunning, Alison M
Easton, Douglas F
Gaborieau, Valerie
Gonzalez-Neira, Anna
Hartman, Mikael 
Healey, Catherine S
Iwasaki, Motoki
John, Esther M
Kang, Daehee
Kim, Sung-Won
Kwong, Ava
Lophatananon, Artitaya
Michailidou, Kyriaki
Taib, Nur Aishah Mohd
Muir, Kenneth
Park, Sue K
Pharoah, Paul IP
Sangrajrang, Suleeporn
Shen, Chen-Yang
Shu, Xiao-Ou
Spinelli, John J
Teo, Soo H
Tessier, Daniel C
Tseng, Chiu-Chen
Tsugane, Shoichiro
Vincent, Daniel
Wang, Qin
Wu, Anna H
Wu, Pei-El
Zheng, Wei
Matsuo, Keitaro
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
acetaldehyde
alcohol drinking
aldehyde dehydrogenase-2
breast cancer
single nucleotide polymorphism
ALDEHYDE DEHYDROGENASE 2
ALCOHOL-DRINKING
GLU504LYS POLYMORPHISM
GENE
CONSUMPTION
HABIT
Issue Date: 1-Jun-2019
Publisher: WILEY
Citation: Ugai, Tomotaka, Milne, Roger L, Ito, Hidemi, Aronson, Kristan J, Bolla, Manjeet K, Chan, Tsun, Chan, Ching W, Choi, Ji-Yeob, Conroy, Don M, Dennis, Joe, Dunning, Alison M, Easton, Douglas F, Gaborieau, Valerie, Gonzalez-Neira, Anna, Hartman, Mikael, Healey, Catherine S, Iwasaki, Motoki, John, Esther M, Kang, Daehee, Kim, Sung-Won, Kwong, Ava, Lophatananon, Artitaya, Michailidou, Kyriaki, Taib, Nur Aishah Mohd, Muir, Kenneth, Park, Sue K, Pharoah, Paul IP, Sangrajrang, Suleeporn, Shen, Chen-Yang, Shu, Xiao-Ou, Spinelli, John J, Teo, Soo H, Tessier, Daniel C, Tseng, Chiu-Chen, Tsugane, Shoichiro, Vincent, Daniel, Wang, Qin, Wu, Anna H, Wu, Pei-El, Zheng, Wei, Matsuo, Keitaro (2019-06-01). The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium. MOLECULAR GENETICS & GENOMIC MEDICINE 7 (6). ScholarBank@NUS Repository. https://doi.org/10.1002/mgg3.707
Abstract: Background: Epidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on acetaldehyde metabolism, the association of rs671 with BC risk and its interaction with alcohol intake have not been fully elucidated. We conducted a pooled analysis of 14 case-control studies, with individual data on Asian ancestry women participating in the Breast Cancer Association Consortium. Methods: We included 12,595 invasive BC cases and 12,884 controls for the analysis of rs671 and BC risk, and 2,849 invasive BC cases and 3,680 controls for the analysis of the gene-environment interaction between rs671 and alcohol intake for BC risk. The pooled odds ratios (OR) with 95% confidence intervals (CI) associated with rs671 and its interaction with alcohol intake for BC risk were estimated using logistic regression models. Results: The Lys/Lys genotype of rs671 was associated with increased BC risk (OR = 1.16, 95% CI 1.03–1.30, p = 0.014). According to tumor characteristics, the Lys/Lys genotype was associated with estrogen receptor (ER)-positive BC (OR = 1.19, 95% CI 1.05–1.36, p = 0.008), progesterone receptor (PR)-positive BC (OR = 1.19, 95% CI 1.03–1.36, p = 0.015), and human epidermal growth factor receptor 2 (HER2)-negative BC (OR = 1.25, 95% CI 1.05–1.48, p = 0.012). No evidence of a gene-environment interaction was observed between rs671 and alcohol intake (p = 0.537). Conclusion: This study suggests that the Lys/Lys genotype confers susceptibility to BC risk among women of Asian ancestry, particularly for ER-positive, PR-positive, and HER2-negative tumor types.
Source Title: MOLECULAR GENETICS & GENOMIC MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/208266
ISSN: 23249269
DOI: 10.1002/mgg3.707
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