Please use this identifier to cite or link to this item:
https://doi.org/10.1158/1541-7786.MCR-16-0275-T
Title: | LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML | Authors: | Zhou, Jianbiao Chan, Zit-Liang Bi, Chonglei Lu, Xiao Chong, Phyllis SY Chooi, Jing-Yuan Cheong, Lip-Lee Liu, Shaw-Cheng Ching, Ying Qing Zhou, Yafeng Osato, Motomi Tan, Tuan Zea Ng, Chin Hin Ng, Siok-Bian Wang, Shi Zeng, Qi Chng, Wee-Joo |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology Cell Biology ACUTE MYELOID-LEUKEMIA MONOCLONAL-ANTIBODIES MICRORNA BIOGENESIS REGENERATING LIVER PHOSPHATASE PRL-3 CANCER METASTASIS EXPRESSION PROTEIN TARGET |
Issue Date: | 1-Mar-2017 | Publisher: | AMER ASSOC CANCER RESEARCH | Citation: | Zhou, Jianbiao, Chan, Zit-Liang, Bi, Chonglei, Lu, Xiao, Chong, Phyllis SY, Chooi, Jing-Yuan, Cheong, Lip-Lee, Liu, Shaw-Cheng, Ching, Ying Qing, Zhou, Yafeng, Osato, Motomi, Tan, Tuan Zea, Ng, Chin Hin, Ng, Siok-Bian, Wang, Shi, Zeng, Qi, Chng, Wee-Joo (2017-03-01). LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML. MOLECULAR CANCER RESEARCH 15 (3) : 294-303. ScholarBank@NUS Repository. https://doi.org/10.1158/1541-7786.MCR-16-0275-T | Abstract: | PRL-3 (PTP4A3), a metastasis-associated phosphatase, is also upregulated in patients with acute myeloid leukemia (AML) and is associated with poor prognosis, but the underlying molecular mechanism is unknown. Here, constitutive expression of PRL-3 in human AML cells sustains leukemogenesis in vitro and in vivo. Furthermore, PRL-3 phosphatase activity dependently upregulates LIN28B, a stem cell reprogramming factor, which in turn represses the let-7 mRNA family, inducing a stem cell-like transcriptional program. Notably, elevated levels of LIN28B protein independently associate with worse survival in AML patients. Thus, these results establish a novel signaling axis involving PRL-3/LIN28B/let-7, which confers stem cell-like properties to leukemia cells that is important for leukemogenesis. Implications: The current study of fers a rationale for targeting PRL-3 as a therapeutic approach for a subset of AML patients with poor prognosis. | Source Title: | MOLECULAR CANCER RESEARCH | URI: | https://scholarbank.nus.edu.sg/handle/10635/207398 | ISSN: | 15417786 15573125 |
DOI: | 10.1158/1541-7786.MCR-16-0275-T |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Zhou J. Mol Cancer Res 2016. LIN28B in AML.pdf | Published version | 1.58 MB | Adobe PDF | CLOSED | Published |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.