Please use this identifier to cite or link to this item: https://doi.org/10.1136/heartjnl-2019-316118
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dc.titleSleep apnoea and cardiovascular outcomes after coronary artery bypass grafting
dc.contributor.authorKoo, Chieh Yang
dc.contributor.authorAung, Aye-Thandar
dc.contributor.authorChen, Zhengfeng
dc.contributor.authorKristanto, William
dc.contributor.authorSim, Hui-Wen
dc.contributor.authorTam, Wilson W
dc.contributor.authorGochuico, Carlo F
dc.contributor.authorTan, Kent Anthony
dc.contributor.authorKang, Giap-Swee
dc.contributor.authorSorokin, Vitaly
dc.contributor.authorOng, Paul Jau Lueng
dc.contributor.authorKojodjojo, Pipin
dc.contributor.authorRichards, Arthur Mark
dc.contributor.authorTan, Huay-Cheem
dc.contributor.authorKofidis, Theodoros
dc.contributor.authorLee, Chi-Hang
dc.date.accessioned2021-11-23T04:21:12Z
dc.date.available2021-11-23T04:21:12Z
dc.date.issued2020-10-01
dc.identifier.citationKoo, Chieh Yang, Aung, Aye-Thandar, Chen, Zhengfeng, Kristanto, William, Sim, Hui-Wen, Tam, Wilson W, Gochuico, Carlo F, Tan, Kent Anthony, Kang, Giap-Swee, Sorokin, Vitaly, Ong, Paul Jau Lueng, Kojodjojo, Pipin, Richards, Arthur Mark, Tan, Huay-Cheem, Kofidis, Theodoros, Lee, Chi-Hang (2020-10-01). Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting. HEART 106 (19) : 1495-+. ScholarBank@NUS Repository. https://doi.org/10.1136/heartjnl-2019-316118
dc.identifier.issn13556037
dc.identifier.issn1468201X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/207359
dc.description.abstractObjective Patients with advanced coronary artery disease are referred for coronary artery bypass grafting (CABG) and it remains unknown if sleep apnoea is a risk marker. We evaluated the association between sleep apnoea and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing non-emergent CABG. Methods This was a prospective cohort study conducted between November 2013 and December 2018. Patients from four public hospitals referred to a tertiary cardiac centre for non-emergent CABG were recruited for an overnight sleep study using a wrist-worn Watch-PAT 200 device prior to CABG. Results Among the 1007 patients who completed the study, sleep apnoea (defined as apnoea-hypopnoea index ≥15 events per hour) was diagnosed in 513 patients (50.9%). Over a mean follow-up period of 2.1 years, 124 patients experienced the four-component MACCE (2-year cumulative incidence estimate, 11.3%). There was a total of 33 cardiac deaths (2.5%), 42 non-fatal myocardial infarctions (3.7%), 50 non-fatal strokes (4.9%) and 36 unplanned revascularisations (3.2%). The crude incidence of MACCE was higher in the sleep apnoea group than the non-sleep apnoea group (2-year estimate, 14.7% vs 7.8%; p=0.002). Sleep apnoea predicted the incidence of MACCE in unadjusted Cox regression analysis (HR 1.69; 95% CI 1.18 to 2.43), and remained statistically significant (adjusted HR 1.57; 95% CI 1.09 to 2.25), after adjustment for age, sex, body mass index, left ventricular ejection fraction, diabetes mellitus, hypertension, chronic kidney disease and excessive daytime sleepiness. Conclusion Sleep apnoea is independently associated with increased MACCE in patients undergoing CABG.
dc.language.isoen
dc.publisherBMJ PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectCardiac & Cardiovascular Systems
dc.subjectCardiovascular System & Cardiology
dc.subjectEVENTS
dc.subjectASSOCIATION
dc.subjectMANAGEMENT
dc.subjectSURGERY
dc.subjectDISEASE
dc.subjectIMPACT
dc.typeArticle
dc.date.updated2021-11-18T05:23:50Z
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF NURSING/ALICE LEE CTR FOR NUR ST
dc.description.doi10.1136/heartjnl-2019-316118
dc.description.sourcetitleHEART
dc.description.volume106
dc.description.issue19
dc.description.page1495-+
dc.published.statePublished
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