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dc.titleHemodynamic analysis of a novel stent graft design with slit perforations in thoracic aortic aneurysm
dc.contributor.authorOng, CW
dc.contributor.authorXiong, F
dc.contributor.authorKabinejadian, F
dc.contributor.authorPraveen Kumar, G
dc.contributor.authorCui, FS
dc.contributor.authorChen, G
dc.contributor.authorHo, P
dc.contributor.authorLeo, HL
dc.identifier.citationOng, CW, Xiong, F, Kabinejadian, F, Praveen Kumar, G, Cui, FS, Chen, G, Ho, P, Leo, HL (2019-03-06). Hemodynamic analysis of a novel stent graft design with slit perforations in thoracic aortic aneurysm. Journal of Biomechanics 85 : 210-217. ScholarBank@NUS Repository.
dc.description.abstractThoracic endovascular aortic repair (TEVAR) has been introduced as a less invasive approach to the treatment of thoracic aortic aneurysm (TAA). However, the effectiveness of TEVAR in the treatment of TAA is often limited due to the complex anatomy of aortic arch. Flow preservation at the three supra-aortic branches further increases the overall technical difficulty. This study proposes a novel stent graft design with slit perforations that can positively alter the hemodynamics at the aortic arch while maintaining blood flow to supra-aortic branches. We carried out a computational fluid dynamic (CFD) analysis to evaluate flow characteristics near stented aortic arch in simplified TAA models, followed by in-vitro experiments using particle image velocimetry (PIV) in a mock circulatory loop. The hemodynamics result was studied in terms of time-averaged wall shear stress (TAWSS), oscillating shear index (OSI), and endothelial cell action potential (ECAP). The results showed that the stent graft with slit perforations can reduce the disturbed flow region considerably. Furthermore, the effect of the slits on flow preservation to the supra-aortic branches was simulated and compared with experimental results. The effectiveness of the stent graft with slit perforations in preserving flow to the branches was demonstrated by both simulated and experimental results. Low TAWSS and elevated ECAP were observed in the aortic arch aneurysm after the placement of the stent graft with slits, implying the potential of thrombus formation in the aneurysm. On the other hand, the effects of the stent grafts with full-slit design and half-slit design on the shear stress did not differ significantly. The present analysis indicated that not only could the stent graft with slit perforations shield the aneurysm from rupture, but also it resulted in a favorable environment for thrombus that can contribute to the shrinkage of the aneurysm.
dc.publisherElsevier BV
dc.subjectComputational fluid dynamics
dc.subjectFlow preservation
dc.subjectParticle image velocimetry
dc.subjectShear stress
dc.subjectThoracic aortic aneurysm
dc.subjectAortic Aneurysm, Thoracic
dc.subjectBlood Vessel Prosthesis
dc.subjectModels, Cardiovascular
dc.subjectProsthesis Design
dc.subjectStress, Mechanical
dc.subjectTreatment Outcome
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.contributor.departmentDEPT OF SURGERY
dc.description.sourcetitleJournal of Biomechanics
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