Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2021.121262
Title: High molecular weight hyper-branched PCL-based thermogelling vitreous endotamponades
Authors: Lin, Qianyu
LIU ZENGPING 
Wong, Daniel SL
Lim, Chen Chuan
Liu, Connie K
Guo, Liangfeng
Zhao, Xinxin
Boo, Yi Jian
Wong, Joey HM
Tan, Rebekah PT
Xue, Kun
Lim, Jason YC
SU XINYI 
XIAN JUN LOH
Issue Date: Nov-2021
Publisher: Elsevier BV
Citation: Lin, Qianyu, LIU ZENGPING, Wong, Daniel SL, Lim, Chen Chuan, Liu, Connie K, Guo, Liangfeng, Zhao, Xinxin, Boo, Yi Jian, Wong, Joey HM, Tan, Rebekah PT, Xue, Kun, Lim, Jason YC, SU XINYI, XIAN JUN LOH (2021-11). High molecular weight hyper-branched PCL-based thermogelling vitreous endotamponades. Biomaterials : 121262-121262. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2021.121262
Abstract: Vitreous endotamponades play essential roles in facilitating retina recovery following vitreoretinal surgery, yet existing clinically standards are suboptimal as they can cause elevated intra-ocular pressure, temporary loss of vision, and cataracts while also requiring prolonged face-down positioning and removal surgery. These drawbacks have spurred the development of next-generation vitreous endotamponades, of which supramolecular hydrogels capable of in-situ gelation have emerged as top contenders. Herein, we demonstrate thermogels formed from hyper-branched amphiphilic copolymers as effective transparent and biodegradable vitreous endotamponades for the first time. These hyper-branched copolymers are synthesised via polyaddition of polyethylene glycol, polypropylene glycol, poly(ε-caprolactone)-diol, and glycerol (branch inducing moiety) with hexamethylene diisocyanate. The hyper-branched thermogels are injected as sols and undergo spontaneous gelation when warmed to physiological temperatures in rabbit eyes. We found that polymers with an optimal degree of hyper-branching showed excellent biocompatibility and was able to maintain retinal function with minimal atrophy and inflammation, even at absolute molecular weights high enough to cause undesirable in-vivo effects for their linear counterparts. The hyper-branched thermogel is cleared naturally from the vitreous through surface hydrogel erosion and negates surgical removal. Our findings expand the scope of polymer architectures suitable for in-vivo intraocular therapeutic applications beyond linear constructs.
Source Title: Biomaterials
URI: https://scholarbank.nus.edu.sg/handle/10635/206773
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2021.121262
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