Please use this identifier to cite or link to this item: https://doi.org/10.1039/c9bm01603a
Title: A new highly transparent injectable PHA-based thermogelling vitreous substitute
Authors: Xue, Kun
LIU ZENGPING 
Jiang, Lu
Kai, Dan
Li, Zibiao
SU XINYI 
XIAN JUN LOH
Keywords: Science & Technology
Technology
Materials Science, Biomaterials
Materials Science
HYDROGELS
BIOMATERIALS
Issue Date: 7-Feb-2020
Publisher: ROYAL SOC CHEMISTRY
Citation: Xue, Kun, LIU ZENGPING, Jiang, Lu, Kai, Dan, Li, Zibiao, SU XINYI, XIAN JUN LOH (2020-02-07). A new highly transparent injectable PHA-based thermogelling vitreous substitute. BIOMATERIALS SCIENCE 8 (3) : 926-936. ScholarBank@NUS Repository. https://doi.org/10.1039/c9bm01603a
Abstract: Transparency is an important criterion for the application of biomaterials to the eye and essential for use as a vitreous substitute. However, there is a lack of understanding on the features of transparent hydrogels and the boundaries of transparency of various hydrogel systems. In this paper, we tune the poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate] (PHBHx) content of biodegradable PHBHx-based polyurethane thermogels and show that the amount of hydrophobic PHBHx correlates with hydrogel cloudiness. We found that PHxEP-0.5 hydrogel shows high light transmittance and suitable gel properties as a vitreous substitute. The PHxEP-0.5 hydrogel is able to maintain transparency when implanted in rabbit eyes as opposed to a cloudy gel and shows negligible inflammation and preservation of the retinal structure over 6 months. In conclusion, we show that PHBHx-based thermogels can be tuned for transparency and are biocompatible in the rabbit eye. These results could be instructive for the design of a new generation of injectable transparent vitreous substitutes.
Source Title: BIOMATERIALS SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/206769
ISSN: 2047-4830
2047-4849
DOI: 10.1039/c9bm01603a
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