Please use this identifier to cite or link to this item: https://doi.org/10.3389/fonc.2021.626659
Title: Characterization and Establishment of a Novel EBV Strain Simultaneously Associated With Nasopharyngeal Carcinoma and B-Cell Lymphoma
Authors: Yu, Fenggang 
Syn, Nicholas L
Lu, Yanan
Chong, Qing Yun 
Lai, Junyun 
Tan, Wei Jian 
Goh, Boon Cher 
MacAry, Paul A 
Wang, Lingzhi 
Loh, Kwok Seng 
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Epstein-Barr virus
nasopharyngeal carcinoma
B cell lymphoma
latent membrane protein 1
viral miRNAs
Issue Date: 7-Apr-2021
Publisher: FRONTIERS MEDIA SA
Citation: Yu, Fenggang, Syn, Nicholas L, Lu, Yanan, Chong, Qing Yun, Lai, Junyun, Tan, Wei Jian, Goh, Boon Cher, MacAry, Paul A, Wang, Lingzhi, Loh, Kwok Seng (2021-04-07). Characterization and Establishment of a Novel EBV Strain Simultaneously Associated With Nasopharyngeal Carcinoma and B-Cell Lymphoma. FRONTIERS IN ONCOLOGY 11. ScholarBank@NUS Repository. https://doi.org/10.3389/fonc.2021.626659
Abstract: © Copyright © 2021 Yu, Syn, Lu, Chong, Lai, Tan, Goh, MacAry, Wang and Loh. Epstein-Barr virus (EBV)—the prototypical human tumor virus—is responsible for 1–2% of the global cancer burden, but divergent strains seem to exist in different geographical regions with distinct predilections for causing lymphoid or epithelial malignancies. Here we report the establishment and characterization of Yu103, an Asia Pacific EBV strain with a highly remarkable provenance of being derived from nasopharyngeal carcinoma biopsy but subsequently propagated in human B-lymphoma cells and xenograft models. Unlike previously characterized EBV strains which are either predominantly B-lymphotropic or epitheliotropic, Yu103 evinces an uncanny capacity to infect and transform both B-lymphocytes and nasopharyngeal epithelial cells. Genomic and phylogenetic analyses indicated that Yu103 EBV lies midway along the spectrum of EBV strains known to drive lymphomagenesis or carcinogenesis, and harbors molecular features which likely account for its unusual properties. To our knowledge, Yu103 EBV is currently the only EBV isolate shown to drive human nasopharyngeal carcinoma and B-lymphoma, and should therefore provide a powerful novel platform for research on EBV-driven hematological and epithelial malignancies.
Source Title: FRONTIERS IN ONCOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/206460
ISSN: 2234943X
DOI: 10.3389/fonc.2021.626659
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