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Title: FBXW7 in cancer: What has been unraveled thus far?
Authors: Sailo, B.L.
Banik, K.
Girisa, S.
Bordoloi, D.
Fan, L. 
Halim, C.E. 
Wang, H. 
Kumar, A.P. 
Zheng, D.
Mao, X.
Sethi, G. 
Kunnumakkara, A.B.
Keywords: Cancer
SCF complex
Tumor suppressor
Issue Date: 2019
Publisher: MDPI AG
Citation: Sailo, B.L., Banik, K., Girisa, S., Bordoloi, D., Fan, L., Halim, C.E., Wang, H., Kumar, A.P., Zheng, D., Mao, X., Sethi, G., Kunnumakkara, A.B. (2019). FBXW7 in cancer: What has been unraveled thus far?. Cancers 11 (2) : 246. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is considered as a potent tumor suppressor as most of its target substrates can function as potential growth promoters, including c-Myc, Notch, cyclin E, c-JUN, and KLF5. Its regulators include p53, C/EBP-d, Numb, microRNAs, Pin 1, Hes-5, BMI1, Ebp2. Mounting evidence has indicated the involvement of aberrant expression of FBXW7 for tumorigenesis. Moreover, numerous studies have also shown its role in cancer cell chemosensitization, thereby demonstrating the importance of FBXW7 in the development of curative cancer therapy. This comprehensive review emphasizes on the targets, functions, regulators and expression of FBXW7 in different cancers and its involvement in sensitizing cancer cells to chemotherapeutic drugs. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Cancers
ISSN: 2072-6694
DOI: 10.3390/cancers11020246
Rights: Attribution 4.0 International
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