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Title: An update on pharmacological potential of boswellic acids against chronic diseases
Authors: Roy, N.K.
Parama, D.
Banik, K.
Bordoloi, D.
Devi, A.K.
Thakur, K.K.
Padmavathi, G.
Shakibaei, M.
Fan, L. 
Sethi, G. 
Kunnumakkara, A.B.
Keywords: Bioavailability
Boswellic acid
Chronic diseases
Molecular targets
Issue Date: 2019
Publisher: MDPI AG
Citation: Roy, N.K., Parama, D., Banik, K., Bordoloi, D., Devi, A.K., Thakur, K.K., Padmavathi, G., Shakibaei, M., Fan, L., Sethi, G., Kunnumakkara, A.B. (2019). An update on pharmacological potential of boswellic acids against chronic diseases. International Journal of Molecular Sciences 20 (17) : 4101. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Natural compounds, in recent years, have attracted significant attention for their use in the prevention and treatment of diverse chronic diseases as they are devoid of major toxicities. Boswellic acid (BA), a series of pentacyclic triterpene molecules, is isolated from the gum resin of Boswellia serrata and Boswellia carteri. It proved to be one such agent that has exhibited effcacy against various chronic diseases like arthritis, diabetes, asthma, cancer, inflammatory bowel disease, Parkinson’s disease, Alzheimer’s, etc. The molecular targets attributed to its wide range of biological activities include transcription factors, kinases, enzymes, receptors, growth factors, etc. The present review is an attempt to demonstrate the diverse pharmacological uses of BA, along with its underlying molecular mechanism of action against different ailments. Further, this review also discusses the roadblocks associated with the pharmacokinetics and bioavailability of this promising compound and strategies to overcome those limitations for developing it as an effective drug for the clinical management of chronic diseases. © 2019 by the authors.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms20174101
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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