Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers11111623
Title: Destined to die: Apoptosis and pediatric cancers
Authors: Choo, Z. 
Loh, A.H.P.
Chen, Z.X. 
Keywords: Apoptosis
Cancer
Development
Pediatric
Issue Date: 2019
Publisher: MDPI AG
Citation: Choo, Z., Loh, A.H.P., Chen, Z.X. (2019). Destined to die: Apoptosis and pediatric cancers. Cancers 11 (11) : 1623. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers11111623
Rights: Attribution 4.0 International
Abstract: Apoptosis (programmed cell death) is a systematic and coordinated cellular process that occurs in physiological and pathophysiological conditions. Sidestepping or resisting apoptosis is a distinct characteristic of human cancers including childhood malignancies. This review dissects the apoptosis pathways implicated in pediatric tumors. Understanding these pathways not only unraveled key molecules that may serve as potential targets for drug discovery, but also molecular nodes that integrate with other signaling networks involved in processes such as development. This review presents current knowledge of the complex regulatory system that governs apoptosis with respect to other processes in pediatric cancers, so that fresh insights may be derived regarding treatment resistance or for more effective treatment options. © 2019 by the authors.
Source Title: Cancers
URI: https://scholarbank.nus.edu.sg/handle/10635/206275
ISSN: 2072-6694
DOI: 10.3390/cancers11111623
Rights: Attribution 4.0 International
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