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Title: Blending oxytocin and dopamine with everyday creativity
Authors: Chong, A
Tolomeo, S
Xiong, Y
Angeles, D
Cheung, M
Becker, B
Lai, PS
Lei, Z
Malavasi, F
Tang, Q 
Chew, SH
Ebstein, RP
Keywords: ADP-ribosyl Cyclase
ADP-ribosyl Cyclase 1
Antigens, CD
Catechol O-Methyltransferase
Dopamine Agents
GPI-Linked Proteins
Gene Expression Regulation
Gene-Environment Interaction
Membrane Glycoproteins
Polymorphism, Single Nucleotide
Receptors, Dopamine D2
Sex Factors
Young Adult
Issue Date: 1-Dec-2021
Publisher: Springer Science and Business Media LLC
Citation: Chong, A, Tolomeo, S, Xiong, Y, Angeles, D, Cheung, M, Becker, B, Lai, PS, Lei, Z, Malavasi, F, Tang, Q, Chew, SH, Ebstein, RP (2021-12-01). Blending oxytocin and dopamine with everyday creativity. Scientific Reports 11 (1) : 16185-. ScholarBank@NUS Repository.
Abstract: Converging evidence suggests that oxytocin (OT) is associated with creative thinking (CT) and that release of OT depends on ADP ribosyl-cyclases (CD38 and CD157). Neural mechanisms of CT and OT show a strong association with dopaminergic (DA) pathways, yet the link between CT and CD38, CD157, dopamine receptor D2 (DRD2) and catechol-O-methyltransferase (COMT) peripheral gene expression remain inconclusive, thus limiting our understanding of the neurobiology of CT. To address this issue, two principal domains of CT, divergent thinking (AUT), were assessed. In men, both AUT is associated with gene expression of CD38, CD157, and their interaction CD38 × CD157. There were no significant associations for DA expression (DRD2, COMT, DRD2 × COMT) on both CT measures. However, analysis of the interactions of OT and DA systems reveal significant interactions for AUT in men. The full model explained a sizable 39% of the variance in females for the total CT score. The current findings suggest that OT and DA gene expression contributed significantly to cognition and CT phenotype. This provides the first empirical foundation of a more refined understanding of the molecular landscape of CT.
Source Title: Scientific Reports
ISSN: 2045-2322,2045-2322
DOI: 10.1038/s41598-021-95724-x
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