Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fendo.2021.725559
DC Field | Value | |
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dc.title | Crash Landing of Thyroid Storm: A Case Report and Review of the Role of Extra-Corporeal Systems | |
dc.contributor.author | Lim, Shir Lynn | |
dc.contributor.author | Wang, Kangjie | |
dc.contributor.author | Lui, Pak Ling | |
dc.contributor.author | Ramanathan, Kollengode | |
dc.contributor.author | Yang, Samantha Peiling | |
dc.date.accessioned | 2021-11-12T12:18:47Z | |
dc.date.available | 2021-11-12T12:18:47Z | |
dc.date.issued | 2021-08-20 | |
dc.identifier.citation | Lim, Shir Lynn, Wang, Kangjie, Lui, Pak Ling, Ramanathan, Kollengode, Yang, Samantha Peiling (2021-08-20). Crash Landing of Thyroid Storm: A Case Report and Review of the Role of Extra-Corporeal Systems. FRONTIERS IN ENDOCRINOLOGY 12. ScholarBank@NUS Repository. https://doi.org/10.3389/fendo.2021.725559 | |
dc.identifier.issn | 16642392 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/206082 | |
dc.description.abstract | Thyroid storm is a rare but life-threatening endocrinological emergency with significant mortality ranging from 10-30% with multi-organ involvement and failure. In view of the rarity of this condition and efficacy of established first line medical treatment, use of extra-corporeal treatments are uncommon, not well-studied, and its available evidence exists only from case reports and case series. We describe a 28-year-old man who presented with an out-of-hospital cardiac arrest secondary to thyroid storm. Despite conventional first-line pharmacotherapy, he developed cardiogenic shock and circulatory collapse with intravenous esmolol infusion, as well as multi-organ failure. He required therapeutic plasma exchange, concurrent renal replacement therapy, and veno-arterial extra-corporeal membrane oxygenation, one of the few reported cases in the literature. While there was clinical stabilization and improvement in tri-iodothyronine levels on three extra-corporeal systems, he suffered irreversible hypoxic-ischemic brain injury. We reviewed the use of early therapeutic plasma exchange and extra-corporeal membrane oxygenation, as well as the development of other novel extra-corporeal modalities when conventional pharmacotherapy is unsuccessful or contraindicated. This case also highlights the complexities in the management of thyroid storm, calling for caution with beta-blockade use in thyrocardiac disease, with close monitoring and prompt organ support. | |
dc.language.iso | en | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.source | Elements | |
dc.subject | thyroid storm | |
dc.subject | multi-organ failure | |
dc.subject | extra-corporeal membrane oxygenation | |
dc.subject | therapeutic plasma exchange | |
dc.subject | continuous renal replacement therapy | |
dc.subject | out-of-hospital cardiac arrest | |
dc.type | Review | |
dc.date.updated | 2021-11-10T02:43:20Z | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DEPT OF SURGERY | |
dc.description.doi | 10.3389/fendo.2021.725559 | |
dc.description.sourcetitle | FRONTIERS IN ENDOCRINOLOGY | |
dc.description.volume | 12 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Crash Landing of Thyroid Storm A Case Report and Review of the Role of Extra-Corporeal Systems.pdf | 3.73 MB | Adobe PDF | OPEN | Published | View/Download |
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