Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.atherosclerosis.2017.03.041
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dc.titleWhole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome
dc.contributor.authorWang, Alice
dc.contributor.authorKwee, Lydia Coulter
dc.contributor.authorGrass, Elizabeth
dc.contributor.authorNeely, Megan L
dc.contributor.authorGregory, Simon G
dc.contributor.authorFox, Keith AA
dc.contributor.authorArmstrong, Paul W
dc.contributor.authorWhite, Harvey D
dc.contributor.authorOhman, E Magnus
dc.contributor.authorRoe, Matthew T
dc.contributor.authorShah, Svati H
dc.contributor.authorChan, Mark Y
dc.date.accessioned2021-11-12T01:41:14Z
dc.date.available2021-11-12T01:41:14Z
dc.date.issued2017-06-01
dc.identifier.citationWang, Alice, Kwee, Lydia Coulter, Grass, Elizabeth, Neely, Megan L, Gregory, Simon G, Fox, Keith AA, Armstrong, Paul W, White, Harvey D, Ohman, E Magnus, Roe, Matthew T, Shah, Svati H, Chan, Mark Y (2017-06-01). Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome. ATHEROSCLEROSIS 261 : 19-25. ScholarBank@NUS Repository. https://doi.org/10.1016/j.atherosclerosis.2017.03.041
dc.identifier.issn00219150
dc.identifier.issn18791484
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/206027
dc.description.abstractBackground and aims Although circulating microRNA (miRNAs) have emerged as biomarkers predicting mortality in acute coronary syndrome (ACS), more data are needed to understand these mechanisms. Mapping miRNAs to high-risk traits may identify miRNAs involved in pathways conferring risk for poor outcome in ACS. We aim to investigate the relationship between circulating miRNAs and high-risk traits in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods Whole-genome miRNA sequencing was performed on RNA extracted from whole blood of 199 patients with NSTE-ACS. Generalized linear models were used to test associations of miRNAs and 13 high-risk clinical traits, including the Global Registry of Acute Coronary Events (GRACE) score, a widely validated risk score for mortality in NSTE-ACS. Results There were 205 nominally significant miRNA-risk factor associations (p < 0.05) observed. Significant associations occurred most frequently with chronic heart failure (HF) (43 miRs), GRACE risk score (30 miRs), and renal function (32 miRs). In hierarchical cluster analysis, chronic HF and GRACE risk score clustered most tightly together, sharing 14 miRNAs with matching fold-change direction. Controlling for a false discovery rate of 5%, chronic HF was significantly associated with lower circulating levels of miR-3135b (p < 0.0006), miR-126-5p (p < 0.0001), miR-142-5p (p = 0.0004) and miR-144-5p (p = 0.0007), while increasing GRACE risk score inversely correlated with levels of miR-3135b (p < 0.0001) and positively correlated with levels of miR-28-3p (p = 0.0002). Conclusions Circulating miRs clustered around two powerful traits for mortality risk in NSTE-ACS. MiR-3135b, which was under-expressed in chronic HF and increasing GRACE risk score, and miR-28-3p, which has no known association with cardiovascular disease, warrant further investigation.
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectCardiac & Cardiovascular Systems
dc.subjectPeripheral Vascular Disease
dc.subjectCardiovascular System & Cardiology
dc.subjectNon-STE acute coronary syndrome
dc.subjectHigh-risk traits
dc.subjectMicroRNA
dc.subjectGLOBAL REGISTRY
dc.subjectCLOPIDOGREL
dc.subjectIMPACT
dc.subjectMIR-28-3P
dc.subjectMORTALITY
dc.subjectPRASUGREL
dc.subjectQUANTIFICATION
dc.subjectCALCIFICATION
dc.subjectTHERAPEUTICS
dc.subjectEXPRESSION
dc.typeArticle
dc.date.updated2021-11-10T05:09:52Z
dc.contributor.departmentSOLAR ENERGY RESEARCH INST OF S'PORE
dc.description.doi10.1016/j.atherosclerosis.2017.03.041
dc.description.sourcetitleATHEROSCLEROSIS
dc.description.volume261
dc.description.page19-25
dc.published.statePublished
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