Please use this identifier to cite or link to this item: https://doi.org/10.1155/2019/1267475
Title: Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naive Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System
Authors: Yan, Rengna
Hu, Yun
Li, Fengfei
Jiang, Lanlan
Xu, Xiaohua
Wang, Jie
Zhang, Ying
Ye, Lei
Lee, Kok Onn 
Su, Xiaofei
Ma, Jianhua
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
TYPE-2 DIABETIC-PATIENTS
BLOOD-GLUCOSE
PLASMA-GLUCOSE
HYPERGLYCEMIA
COMPLICATIONS
HBA(1C)
INCREMENTS
GLYCEMIA
BASAL
Issue Date: 1-Dec-2019
Publisher: HINDAWI LTD
Citation: Yan, Rengna, Hu, Yun, Li, Fengfei, Jiang, Lanlan, Xu, Xiaohua, Wang, Jie, Zhang, Ying, Ye, Lei, Lee, Kok Onn, Su, Xiaofei, Ma, Jianhua (2019-12-01). Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naive Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2019. ScholarBank@NUS Repository. https://doi.org/10.1155/2019/1267475
Abstract: Aim. To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods. Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or IGT/IFG. The incremental area under the curve (AUC) above a glucose value of 6.1 mmol/L or FG glucose levels were calculated to evaluate the contributions of PG or FG to HbA1c values. Results. According to quintiles of HbA1c, T2D patients were divided into five groups (group 1 to 5), and patients with IGT/IFG were assigned into group 0. PG was the predominant contributor in the lower groups with HbA1c 4.9∼6.0% and 6.1∼7.8%. The relative contributions of FG and PG to HbA1c had no significance in the middle groups of HbA1c (7.9∼8.7% and 8.8∼9.5%). FG contributed significantly more than PG in the higher groups of HbA1c (9.6∼10.9% and 11.0∼14.6%). Regression analyses indicate that the contributions of FG and PG were equal (both 50%) when the level of HbA1c was 8.5%. Conclusions. In drug-naïve patients with T2D or IGT/IFG, PG contributed more in patients with HbA1c < 8.5%, whereas FG became the predominant contributor in the poorly controlled patients with HbA1c ≥ 8.5%. These results may help the health-care provider set appropriate plasma glucose testing goals with the expectation of achieving specific HbA1c values.
Source Title: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/205918
ISSN: 16878337
16878345
DOI: 10.1155/2019/1267475
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