Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s40560-021-00535-x
Title: | The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies | Authors: | Ng, Jun Jie Liang, Zhen Chang Choong, Andrew MTL |
Keywords: | Science & Technology Life Sciences & Biomedicine Critical Care Medicine General & Internal Medicine Coronavirus disease 2019 COVID-19 Pulmonary thromboembolism Intensive care unit Critical care |
Issue Date: | 22-Feb-2021 | Publisher: | BMC | Citation: | Ng, Jun Jie, Liang, Zhen Chang, Choong, Andrew MTL (2021-02-22). The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies. JOURNAL OF INTENSIVE CARE 9 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s40560-021-00535-x | Abstract: | Objectives: Coronavirus disease 2019 (COVID-19) infection is associated with a prothrombotic state. We performed a meta-analysis of proportions to estimate the weighted average incidence of pulmonary thromboembolism (PTE) in COVID-19 patients who were admitted to the intensive care unit (ICU). Methods: We searched various medical databases for relevant studies from 31 December 2019 till 30 September 2020. We included observational studies that reported the incidence of PTE in COVID-19 patients admitted to the ICU. We extracted data related to study characteristics, patient demographics, and the incidence of PTE. Risk of bias was assessed by using the ROBINS-I tool. Statistical analysis was performed with R 3.6.3. Results: We included 14 studies with a total of 1182 patients in this study. Almost all patients in this meta-analysis received at least prophylactic anticoagulation. The weighted average incidence of PTE was 11.1% (95% CI 7.7% to 15.7%, I2 = 78%, Cochran’s Q test P < 0.01). We performed univariate and multivariate meta-regression, which identified the proportion of males as a significant source of heterogeneity (P = 0.03, 95% CI 0.00 to − 0.09) Conclusion: The weighted average incidence of PTE remains high even after prophylactic anticoagulation. PTE is a significant complication of COVID-19 especially in critically ill patients in the ICU. | Source Title: | JOURNAL OF INTENSIVE CARE | URI: | https://scholarbank.nus.edu.sg/handle/10635/205872 | ISSN: | 20520492 | DOI: | 10.1186/s40560-021-00535-x |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit a meta-analysis and meta.pdf | 1.27 MB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.