Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.carrev.2021.04.014
Title: Long-term clinical outcomes of biodegradable polymer drug eluting stents versus second-generation durable polymer drug eluting stents for ST-segment elevation myocardial infarction
Authors: Sim, HW
Thong, EH
Djohan, AH
Chen, JZ 
Ser, JS
Loh, PH 
Lee, CH 
Chan, MY 
Low, AF 
Tay, EL 
Chan, KH 
Tan, HC 
Loh, JP 
Keywords: Biodegradable polymer
Drug eluting stent
Durable polymer
STEMI
Issue Date: 1-Jan-2021
Publisher: Elsevier BV
Citation: Sim, HW, Thong, EH, Djohan, AH, Chen, JZ, Ser, JS, Loh, PH, Lee, CH, Chan, MY, Low, AF, Tay, EL, Chan, KH, Tan, HC, Loh, JP (2021-01-01). Long-term clinical outcomes of biodegradable polymer drug eluting stents versus second-generation durable polymer drug eluting stents for ST-segment elevation myocardial infarction. Cardiovascular Revascularization Medicine. ScholarBank@NUS Repository. https://doi.org/10.1016/j.carrev.2021.04.014
Abstract: Background: Biodegradable polymer drug eluting stents (BP-DES) may offer the advantage of vascular healing in ST-segment elevation myocardial infarction (STEMI). Long-term outcome data comparing BP-DES and second-generation durable polymer drug eluting stents (DP-DES) in STEMI is lacking. This study aims to compare the long-term clinical outcomes of BP-DES versus second-generation DP-DES in STEMI. Methods: This is an observational study of consecutive patients with STEMI who received either BP-DES (n = 854) or DP-DES (n = 708) during primary percutaneous coronary intervention (PCI) from 1st February 2007 to 31st December 2016. The primary outcome was target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (MI), and target lesion revascularization with follow up till 30th November 2019. Results: The baseline demographics, lesion and procedural characteristic were similar between the two groups except for more prior MI and chronic obstructive pulmonary disease in the BP-DES group. At a median follow up of 4.2 years (interquartile range: 2.6–6.2 years), the incidence of TLF was similar between BP-DES and DP-DES (adjusted hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.70–1.26). Likewise, incidence of major adverse cardiovascular events (MACE: all-cause death, any MI or target vessel revascularization) and definite stent thrombosis were similar in both groups (MACE: adjusted HR 1.04, 95% CI 0.82–1.32; definite stent thrombosis: adjusted HR 1.06, 95% CI 0.31–3.64). Conclusion: Among patients with STEMI who underwent primary PCI, BP-DES and DP-DES implantation was associated with similar long-term clinical outcomes.
Source Title: Cardiovascular Revascularization Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/205815
ISSN: 15538389
18780938
DOI: 10.1016/j.carrev.2021.04.014
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