Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s12933-021-01395-3
DC Field | Value | |
---|---|---|
dc.title | Optimal glucose, HbA1c, glucose-HbA1c ratio and stress-hyperglycaemia ratio cut-off values for predicting 1-year mortality in diabetic and non-diabetic acute myocardial infarction patients | |
dc.contributor.author | Sia, Ching-Hui | |
dc.contributor.author | Chan, Mervyn Huan-Hao | |
dc.contributor.author | Zheng, Huili | |
dc.contributor.author | Ko, Junsuk | |
dc.contributor.author | Ho, Andrew Fu-Wah | |
dc.contributor.author | Chong, Jun | |
dc.contributor.author | Foo, David | |
dc.contributor.author | Foo, Ling-Li | |
dc.contributor.author | Lim, Patrick Zhan-Yun | |
dc.contributor.author | Liew, Boon Wah | |
dc.contributor.author | Chai, Ping | |
dc.contributor.author | Yeo, Tiong-Cheng | |
dc.contributor.author | Tan, Huay-Cheem | |
dc.contributor.author | Chua, Terrance | |
dc.contributor.author | Chan, Mark Yan-Yee | |
dc.contributor.author | Tan, Jack Wei Chieh | |
dc.contributor.author | Bulluck, Heerajnarain | |
dc.contributor.author | Hausenloy, Derek J | |
dc.date.accessioned | 2021-11-09T04:35:28Z | |
dc.date.available | 2021-11-09T04:35:28Z | |
dc.date.issued | 2021-10-19 | |
dc.identifier.citation | Sia, Ching-Hui, Chan, Mervyn Huan-Hao, Zheng, Huili, Ko, Junsuk, Ho, Andrew Fu-Wah, Chong, Jun, Foo, David, Foo, Ling-Li, Lim, Patrick Zhan-Yun, Liew, Boon Wah, Chai, Ping, Yeo, Tiong-Cheng, Tan, Huay-Cheem, Chua, Terrance, Chan, Mark Yan-Yee, Tan, Jack Wei Chieh, Bulluck, Heerajnarain, Hausenloy, Derek J (2021-10-19). Optimal glucose, HbA1c, glucose-HbA1c ratio and stress-hyperglycaemia ratio cut-off values for predicting 1-year mortality in diabetic and non-diabetic acute myocardial infarction patients. CARDIOVASCULAR DIABETOLOGY 20 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12933-021-01395-3 | |
dc.identifier.issn | 14752840 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/205735 | |
dc.description.abstract | Background: Stress-induced hyperglycaemia at time of hospital admission has been linked to worse prognosis following acute myocardial infarction (AMI). In addition to glucose, other glucose-related indices, such as HbA1c, glucose-HbA1c ratio (GHR), and stress-hyperglycaemia ratio (SHR) are potential predictors of clinical outcomes following AMI. However, the optimal blood glucose, HbA1c, GHR, and SHR cut-off values for predicting adverse outcomes post-AMI are unknown. As such, we determined the optimal blood glucose, HbA1c, GHR, and SHR cut-off values for predicting 1-year all cause mortality in diabetic and non-diabetic ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) patients. Methods: We undertook a national, registry-based study of patients with AMI from January 2008 to December 2015. We determined the optimal blood glucose, HbA1c, GHR, and SHR cut-off values using the Youden’s formula for 1-year all-cause mortality. We subsequently analyzed the sensitivity, specificity, positive and negative predictive values of the cut-off values in the diabetic and non-diabetic subgroups, stratified by the type of AMI. Results: There were 5841 STEMI and 4105 NSTEMI in the study. In STEMI patients, glucose, GHR, and SHR were independent predictors of 1-year all-cause mortality [glucose: OR 2.19 (95% CI 1.74–2.76); GHR: OR 2.28 (95% CI 1.80–2.89); SHR: OR 2.20 (95% CI 1.73–2.79)]. However, in NSTEMI patients, glucose and HbA1c were independently associated with 1-year all-cause mortality [glucose: OR 1.38 (95% CI 1.01–1.90); HbA1c: OR 2.11 (95% CI 1.15–3.88)]. In diabetic STEMI patients, SHR performed the best in terms of area-under-the-curve (AUC) analysis (glucose: AUC 63.3%, 95% CI 59.5–67.2; GHR 68.8% 95% CI 64.8–72.8; SHR: AUC 69.3%, 95% CI 65.4–73.2). However, in non-diabetic STEMI patients, glucose, GHR, and SHR performed equally well (glucose: AUC 72.0%, 95% CI 67.7–76.3; GHR 71.9% 95% CI 67.7–76.2; SHR: AUC 71.7%, 95% CI 67.4–76.0). In NSTEMI patients, glucose performed better than HbA1c for both diabetic and non-diabetic patients in AUC analysis (For diabetic, glucose: AUC 52.8%, 95% CI 48.1–57.6; HbA1c: AUC 42.5%, 95% CI 37.6–47. For non-diabetic, glucose: AUC 62.0%, 95% CI 54.1–70.0; HbA1c: AUC 51.1%, 95% CI 43.3–58.9). The optimal cut-off values for glucose, GHR, and SHR in STEMI patients were 15.0 mmol/L, 2.11, and 1.68 for diabetic and 10.6 mmol/L, 1.72, and 1.51 for non-diabetic patients respectively. For NSTEMI patients, the optimal glucose values were 10.7 mmol/L for diabetic and 8.1 mmol/L for non-diabetic patients. Conclusions: SHR was the most consistent independent predictor of 1-year all-cause mortality in both diabetic and non-diabetic STEMI, whereas glucose was the best predictor in NSTEMI patients. | |
dc.language.iso | en | |
dc.publisher | BMC | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cardiac & Cardiovascular Systems | |
dc.subject | Endocrinology & Metabolism | |
dc.subject | Cardiovascular System & Cardiology | |
dc.subject | ST-SEGMENT ELEVATION | |
dc.subject | CARBOHYDRATE-METABOLISM | |
dc.subject | RELATIVE HYPERGLYCEMIA | |
dc.subject | TASK-FORCE | |
dc.subject | ASSOCIATION | |
dc.subject | ADMISSION | |
dc.subject | MANAGEMENT | |
dc.subject | INFUSION | |
dc.subject | CURVES | |
dc.subject | INDEX | |
dc.type | Article | |
dc.date.updated | 2021-11-08T15:05:32Z | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1186/s12933-021-01395-3 | |
dc.description.sourcetitle | CARDIOVASCULAR DIABETOLOGY | |
dc.description.volume | 20 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Optimal glucose, HbA1c, glucose-HbA1c ratio and stress-hyperglycaemia ratio cut-off values for predicting 1-year mortality in diabetic and non-diabetic acute myocardial infarction patients..pdf | 1.15 MB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.