Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41389-021-00342-x
Title: Tumour heterogeneity and evolutionary dynamics in colorectal cancer
Authors: Chan, Dedrick Kok Hong 
Buczacki, Simon James Alexander
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
CONSENSUS MOLECULAR SUBTYPES
CPG ISLAND METHYLATION
MICROSATELLITE INSTABILITY
CHROMOSOMAL INSTABILITY
CELL HETEROGENEITY
CLONAL EVOLUTION
BRAF MUTATION
STEM-CELLS
PHENOTYPE
PROGNOSIS
Issue Date: 16-Jul-2021
Publisher: SPRINGERNATURE
Citation: Chan, Dedrick Kok Hong, Buczacki, Simon James Alexander (2021-07-16). Tumour heterogeneity and evolutionary dynamics in colorectal cancer. ONCOGENESIS 10 (7). ScholarBank@NUS Repository. https://doi.org/10.1038/s41389-021-00342-x
Abstract: Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC has progressed from initial discoveries which focused on the stepwise accumulation of key driver mutations, as encapsulated in the Vogelstein model, to one in which marked heterogeneity leads to a complex interplay between clonal populations. Current evidence suggests that an initial explosion, or “Big Bang”, of genetic diversity is followed by a period of neutral dynamics. A thorough understanding of this interplay between clonal populations during neutral evolution gives insights into the roles in which driver genes may participate in the progress from normal colonic epithelium to adenoma and carcinoma. Recent advances have focused not only on genetics, transcriptomics, and proteomics but have also investigated the ecological and evolutionary processes which transform normal cells into cancer. This review first describes the role which driver mutations play in the Vogelstein model and subsequently demonstrates the evidence which supports a more complex model. This article also aims to underscore the significance of tumour heterogeneity and diverse clonal populations in cancer progression.
Source Title: ONCOGENESIS
URI: https://scholarbank.nus.edu.sg/handle/10635/205715
ISSN: 21579024
DOI: 10.1038/s41389-021-00342-x
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