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https://doi.org/10.1016/j.canlet.2021.10.013
Title: | Blood-based liquid biopsy: Insights into early detection and clinical management of lung cancer | Authors: | Liu, Cuiliu Xiang, Xiaoqiang Han, Shuangqing Lim, Hannah Ying Li, Lingrui Zhang, Xing Ma, Zhaowu Yang, Li Guo, Shuliang Soo, Ross Ren, Boxu Wang, L.-Z. Goh, B.C. |
Keywords: | liquid biopsy Biomarkers lung cancer Early detection Clinical management |
Issue Date: | 1-Jan-2022 | Publisher: | Elsevier BV | Citation: | Liu, Cuiliu, Xiang, Xiaoqiang, Han, Shuangqing, Lim, Hannah Ying, Li, Lingrui, Zhang, Xing, Ma, Zhaowu, Yang, Li, Guo, Shuliang, Soo, Ross, Ren, Boxu, Wang, L.-Z., Goh, B.C. (2022-01-01). Blood-based liquid biopsy: Insights into early detection and clinical management of lung cancer. Cancer Letters 524 : 91-102. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2021.10.013 | Abstract: | Currently, early detection of lung cancer relies on the characterisation of images generated from computed tomography (CT). However, lung tissue biopsy, a highly invasive surgical procedure, is required to confirm CTderived diagnostic results with very high false-positive rates. Hence, a non-invasive or minimally invasive biomarkers is essential to complement the existing low-dose CT (LDCT) for early detection, improve responses to a certain treatment, predict cancer recurrence, and to evaluate prognosis. In the past decade, liquid biopsies (e.g., blood) have been demonstrated to be highly effective for lung cancer biomarker discovery. In this review, the roles of emerging liquid biopsy-derived biomarkers such as circulating nucleic acids, circulating tumour cells (CTCs), long non-coding RNA (lncRNA), and microRNA (miRNA), as well as exosomes, have been highlighted. The advantages and limitations of these blood-based minimally invasive biomarkers have been discussed. Furthermore, the current progress of the identified biomarkers for clinical management of lung cancer has been summarised. Finally, a potential strategy for the early detection of lung cancer, using a combination of LDCT scans and well-validated biomarkers, has been discussed. | Source Title: | Cancer Letters | URI: | https://scholarbank.nus.edu.sg/handle/10635/204076 | ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2021.10.013 |
Appears in Collections: | Staff Publications Elements |
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