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Title: Development of a bioresorbable bone graft alternative for bone engineering applications
Keywords: bone engineering, scaffold, bioresorbable, polycaprolactone, bmp-2
Issue Date: 8-Apr-2010
Citation: CHRISTOPHER LAM XU FU (2010-04-08). Development of a bioresorbable bone graft alternative for bone engineering applications. ScholarBank@NUS Repository.
Abstract: Clinically, autografts are the ?ideal? bone grafts but have several limitations. An ?ideal? bone graft alternative could be developed with tissue engineering strategies utilizing biomaterials to create a scaffold system encompassing the advantages of autografts (osteoinductivity and mechanical stability) while overcoming its limitations, which could be a potential ?off the shelf? graft. Composite (PCL/TCP) scaffolds, fabricated using rapid prototyping technology with FDA approved materials, possess functional mechanical properties and are suitable carriers for osteoinductive BMP-2, to support cell growth, differentiation and tissue regeneration. In this present study, the degradation profile and mechanisms were studied in vitro and in vivo, up to five and two years, respectively. The scaffold system was assessed for its suitability, function and performance as a tissue engineering bone graft in a rat calvarial defect and porcine spinal fusion model, up to 4 and 9 months, respectively. Spinal fusion results of ?CT and histology revealed bone tissue repair and scaffold integration into host bone bed. Further, biomechanical assessment showed adequate functional stability, compared to autograft controls.
Appears in Collections:Ph.D Theses (Open)

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