Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/203038
Title: Effect of intra-patient variability on personalized parameters of glucose-insulin dynamic models for exercise, meal, and insulin interventions
Authors: NAVIYN PRABHU BALAKRISHNAN 
Lakshminarayanan, S. 
Rangaiah, G.P. 
Keywords: Model reduction
Parameter Estimation
Parameter Identification
Statistical Analysis
Uncertainty
Validation
Issue Date: 1-Jan-2013
Publisher: Elsevier BV
Citation: NAVIYN PRABHU BALAKRISHNAN, Lakshminarayanan, S., Rangaiah, G.P. (2013-01-01). Effect of intra-patient variability on personalized parameters of glucose-insulin dynamic models for exercise, meal, and insulin interventions. IFAC Proceedings Volumes (IFAC-PapersOnline) 12 (PART 1) : 338-343. ScholarBank@NUS Repository.
Abstract: The objective of this paper is to study the effect of intra-patient variations on the personalized parameters of the modified exercise minimal model by re-estimating them from the clinical data measured after several days of first estimation. Clinical data of eight type 1 diabetic children and adolescents have been used for this purpose. For the first estimation of 6 estimable parameters, clinical data collected during one of the visits have been employed. Subsequent re-estimation of parameters is accomplished using the second clinical visit data, which was collected after 7-35 days from the first visit. The results of re-estimation indicate that the estimable parameters corresponding to glucose-insulin compartments and meal absorption model are greatly affected by intra-patient variability in most of the patients, while the 2 estimable parameters corresponding to exercise compartments are least affected by intra-patient variations in 6 out of 8 patients. © IFAC.
Source Title: IFAC Proceedings Volumes (IFAC-PapersOnline)
URI: https://scholarbank.nus.edu.sg/handle/10635/203038
ISBN: 9783902823588
ISSN: 1474-6670
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