Please use this identifier to cite or link to this item: https://doi.org/10.4049/jimmunol.1900978
Title: BHLHE40 Promotes T(H)2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines
Authors: Jarjour, Nicholas N
Bradstreet, Tara R
Schwarzkopf, Elizabeth A
Cook, Melissa E
Lai, Chin-Wen
Huang, Stanley Ching-Cheng
RESHMA TANEJA 
Stappenbeck, Thaddeus S
Van Dyken, Steven J
Urban, Joseph F
Edelson, Brian T
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
COLONY-STIMULATING FACTOR
GM-CSF
INFECTION
PROTECTION
RESPONSES
MICE
IL-3
TH2
NEUTRALIZATION
ACTIVATION
Issue Date: 15-Feb-2020
Publisher: American Association of Immunologists
Citation: Jarjour, Nicholas N, Bradstreet, Tara R, Schwarzkopf, Elizabeth A, Cook, Melissa E, Lai, Chin-Wen, Huang, Stanley Ching-Cheng, RESHMA TANEJA, Stappenbeck, Thaddeus S, Van Dyken, Steven J, Urban, Joseph F, Edelson, Brian T (2020-02-15). BHLHE40 Promotes T(H)2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines. JOURNAL OF IMMUNOLOGY 204 (4) : 923-932. ScholarBank@NUS Repository. https://doi.org/10.4049/jimmunol.1900978
Abstract: The transcription factor BHLHE40 is an emerging regulator of the immune system. Recent studies suggest that BHLHE40 regulates type 2 immunity, but this has not been demonstrated in vivo.We found that BHLHE40 is required in T cells for a protective TH2 cell response in mice infected with the helminth Heligmosomoides polygyrus bakeri. H. polygyrus elicited changes in gene and cytokine expression by lamina propria CD4+ T cells, many of which were BHLHE40 dependent, including production of the common b (CSF2RB) chain family cytokines GM-CSF and IL-5. In contrast to deficiency in GM-CSF or IL-5 alone, loss of both GM-CSF and IL-5 signaling impaired protection against H. polygyrus. Overall, we show that BHLHE40 regulates the TH2 cell transcriptional program during helminth infection to support normal expression of Csf2, Il5, and other genes required for protection and reveal unexpected redundancy of common b chain-dependent cytokines previously thought to possess substantially divergent functions.
Source Title: JOURNAL OF IMMUNOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/200312
ISSN: 0022-1767
1550-6606
DOI: 10.4049/jimmunol.1900978
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