Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.asjsur.2020.01.005
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dc.titleApplicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center
dc.contributor.authorWong, R.X.
dc.contributor.authorKoh, Y.S.
dc.contributor.authorOng, F.
dc.contributor.authorFarid, M.
dc.contributor.authorTay, T.K.Y.
dc.contributor.authorTeo, M.
dc.date.accessioned2021-08-23T03:23:21Z
dc.date.available2021-08-23T03:23:21Z
dc.date.issued2020-11
dc.identifier.citationWong, R.X., Koh, Y.S., Ong, F., Farid, M., Tay, T.K.Y., Teo, M. (2020-11). Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center. Asian Journal of Surgery 43 (11) : 1078-1085. ScholarBank@NUS Repository. https://doi.org/10.1016/j.asjsur.2020.01.005
dc.identifier.issn10159584
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/198742
dc.description.abstractAim: To study the applicability of 2 common nomograms in retroperitoneal sarcoma patients treated in an Asian tertiary hospital, and to study relapse patterns. Methods: Patients from 1st January 2000 to 31st December 2017 were retrospectively analysed. R2 resection from an external institution were ineligible. Harrel's C concordance index and calibration plots were used to assess nomograms' accuracy. Results: 109 patients were eligible, with a median age of 56, median tumour size of 16 cm and median follow up of 44.1 months. Most common subtypes were DDLPS (46.8%), LMS (19.3%) and WDLPS (13.8%). Overall, 81.1% had passed away from sarcoma. Recurrence patterns differed with subtypes; 6.7% of WDLPS and 66.7% of LMS had distant relapses. WDLPS patients had a median sarcoma specific survival of 139 months (122-NA), while the rest had a median SSS of 72.3 months (59.7-NA). The 5-years and 7-year OS were 63.0% (95% CI: 53.6%–74.0%) and 51.6% (41.1%–64.8%) respectively. The 5-years and 7-year DFS were 22.4% (15.5%–32.3%) and 17.5% (11%–27.8%) respectively. The 4-years, 8-years and 12-year SSS were 71.3% (62.7%–81.0%), 51.8% (40.8%–65.8%) and 32.2% (19.7%–52.6%) respectively. The concordance indices for 7-year DFS and OS (Sarculator) were 0.63 and 0.73. The concordance indices for 4-, 8- and 12-year SSS (MSKCC) were 0.64, 0.72 and 0.72. Conclusion: Both nomograms were effective in our cohort. Both nomograms can be further improved by specifying the type of relapse and including a longer-term endpoint for the Sarculator. © 2020
dc.publisherElsevier (Singapore) Pte Ltd
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2020
dc.subjectNeoplasm grading
dc.subjectNomograms
dc.subjectPeritoneum
dc.subjectSarcoma
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.asjsur.2020.01.005
dc.description.sourcetitleAsian Journal of Surgery
dc.description.volume43
dc.description.issue11
dc.description.page1078-1085
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