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https://doi.org/10.1038/s41467-020-19061-9
Title: | Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics | Authors: | Zhang, Y. Wang, X. Chu, C. Zhou, Z. Chen, B. Pang, X. Lin, G. Lin, H. Guo, Y. Ren, E. Lv, P. Shi, Y. Zheng, Q. Yan, X. Chen, X. Liu, G. |
Issue Date: | 27-Oct-2020 | Publisher: | Nature Research | Citation: | Zhang, Y., Wang, X., Chu, C., Zhou, Z., Chen, B., Pang, X., Lin, G., Lin, H., Guo, Y., Ren, E., Lv, P., Shi, Y., Zheng, Q., Yan, X., Chen, X., Liu, G. (2020-10-27). Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics. Nature Communications 11 (1) : 5421. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-19061-9 | Rights: | Attribution 4.0 International | Abstract: | The clinical applications of magnetic hyperthermia therapy (MHT) have been largely hindered by the poor magnetic-to-thermal conversion efficiency of MHT agents. Herein, we develop a facile and efficient strategy for engineering encapsulin-produced magnetic iron oxide nanocomposites (eMIONs) via a green biomineralization procedure. We demonstrate that eMIONs have excellent magnetic saturation and remnant magnetization properties, featuring superior magnetic-to-thermal conversion efficiency with an ultrahigh specific absorption rate of 2390 W/g to overcome the critical issues of MHT. We also show that eMIONs act as a nanozyme and have enhanced catalase-like activity in the presence of an alternative magnetic field, leading to tumor angiogenesis inhibition with a corresponding sharp decrease in the expression of HIF-1α. The inherent excellent magnetic-heat capability, coupled with catalysis-triggered tumor suppression, allows eMIONs to provide an MRI-guided magneto-catalytic combination therapy, which may open up a new avenue for bench-to-bed translational research of MHT. © 2020, The Author(s). | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/198633 | ISSN: | 20411723 | DOI: | 10.1038/s41467-020-19061-9 | Rights: | Attribution 4.0 International |
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