Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphys.2020.00137
Title: The Unresolved Pathophysiology of Lymphedema
Authors: Azhar, S.H. 
Lim, H.Y. 
Tan, B.-K. 
Angeli, V. 
Keywords: adipose tissue
fibrosis
inflammation
lymphedema
pathophysiology
Issue Date: 17-Mar-2020
Publisher: Frontiers Media S.A.
Citation: Azhar, S.H., Lim, H.Y., Tan, B.-K., Angeli, V. (2020-03-17). The Unresolved Pathophysiology of Lymphedema. Frontiers in Physiology 11 : 137. ScholarBank@NUS Repository. https://doi.org/10.3389/fphys.2020.00137
Rights: Attribution 4.0 International
Abstract: Lymphedema is the clinical manifestation of impaired lymphatic transport. It remains an under-recognized and under-documented clinical condition that still lacks a cure. Despite the substantial advances in the understanding of lymphatic vessel biology and function in the past two decades, there are still unsolved questions regarding the pathophysiology of lymphedema, especially in humans. As a consequence of impaired lymphatic drainage, proteins and lipids accumulate in the interstitial space, causing the regional tissue to undergo extensive and progressive architectural changes, including adipose tissue deposition and fibrosis. These changes are also associated with inflammation. However, the temporal sequence of these events, the relationship between these events, and their interplay during the progression are not clearly understood. Here, we review our current knowledge on the pathophysiology of lymphedema derived from human and animal studies. We also discuss the possible cellular and molecular mechanisms involved in adipose tissue and collagen accumulation during lymphedema. We suggest that more studies should be dedicated to enhancing our understanding of the human pathophysiology of lymphedema to pave the way for new diagnostic and therapeutic avenues for this condition. © Copyright © 2020 Azhar, Lim, Tan and Angeli.
Source Title: Frontiers in Physiology
URI: https://scholarbank.nus.edu.sg/handle/10635/198593
ISSN: 1664042X
DOI: 10.3389/fphys.2020.00137
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fphys_2020_00137.pdf330.64 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

39
checked on Sep 30, 2022

Page view(s)

95
checked on Sep 29, 2022

Download(s)

11
checked on Sep 29, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons