Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.scr.2020.101880
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dc.titleTissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus
dc.contributor.authorKong, C.M.
dc.contributor.authorArjunan, S.
dc.contributor.authorGan, S.U.
dc.contributor.authorArijit, B.
dc.contributor.authorBongso, Ariff
dc.contributor.authorFong, C.-Y.
dc.date.accessioned2021-08-18T03:57:01Z
dc.date.available2021-08-18T03:57:01Z
dc.date.issued2020
dc.identifier.citationKong, C.M., Arjunan, S., Gan, S.U., Arijit, B., Bongso, Ariff, Fong, C.-Y. (2020). Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus. Stem Cell Research 47 : 101880. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2020.101880
dc.identifier.issn18735061
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/197657
dc.description.abstractGestational diabetes mellitus (GDM) has been strongly associated with an increased risk of type 2 diabetes mellitus (T2DM) in later child and adulthood. The human umbilical cord and its contents are of fetal origin and represent the fetus genetically and physiologically. Since it is not possible to obtain tissues from the fetus and newborn to investigate the association between GDM and later T2DM, we reprogrammed the stem cells from the Wharton's jelly of umbilical cords (hWJSCs) of GDM and non-GDM mothers into induced pluripotent stem cells (iPSCs) and then differentiated the iPSCs into insulin-producing cells (IPCs) to provide pancreatic tissues that represent the fetus of GDM and normal mothers. These tissues are an attractive model to study the effects of glucose on the fetus. Interestingly, GDM-iPSCs had a decreased potential towards differentiation into IPCs. IPCs differentiated from GDM-iPSCs also had lower total insulin content and a lower capacity for insulin secretion to glucose stimulation compared to their normal-iPSC counterparts. This abnormal pathogenesis in GDM-iPSCs pancreatic differentiation recapitulates the pathology that may be observed in the infants of the diabetic mother (IDM) and while indicating adaptive mechanisms for fetal survival, may lead to the development of T2DM later in life. (199 words) � 2020 The Author(s)
dc.publisherElsevier B.V.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2020
dc.subjectGestational diabetes mellitus
dc.subjectInduced pluripotent stem cells
dc.subjectPancreatic cells
dc.subjectReprogramming
dc.subjectWharton's jelly stem cells
dc.typeArticle
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.1016/j.scr.2020.101880
dc.description.sourcetitleStem Cell Research
dc.description.volume47
dc.description.page101880
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