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https://doi.org/10.1186/s12889-020-09530-7
Title: | Reproductive factors and lung cancer risk: A comprehensive systematic review and meta-analysis | Authors: | Yin, X. Zhu, Z. Hosgood, H.D. Lan, Q. Seow, W.J. |
Keywords: | Lung cancer Meta-analysis Never-smokers Parity Reproductive factors |
Issue Date: | 2020 | Publisher: | BioMed Central Ltd | Citation: | Yin, X., Zhu, Z., Hosgood, H.D., Lan, Q., Seow, W.J. (2020). Reproductive factors and lung cancer risk: A comprehensive systematic review and meta-analysis. BMC Public Health 20 (1) : 1458. ScholarBank@NUS Repository. https://doi.org/10.1186/s12889-020-09530-7 | Rights: | Attribution 4.0 International | Abstract: | Background: A number of studies have investigated the association between reproductive factors and lung cancer risk, however findings are inconsistent. This meta-analysis aimed to evaluate the association between female reproductive factors and lung cancer risk. Methods: We conducted a comprehensive systematic search to identify relevant and eligible studies published before 18th December 2019. Inter-study heterogeneity was assessed using the Q test and I 2 statistic. Based on the heterogeneity of each reproductive factor, fixed or random effects models were used to calculate the summary odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses by study design, lung cancer subtypes, smoking status, and ethnicity were also performed. Results: A total of 66 studies with 20 distinct reproductive factors were included in this meta-analysis. Comparing the highest and lowest categories (reference) of each reproductive factor, parity (OR = 0.83, 95% CI = 0.72-0.96), menstrual cycle length (OR = 0.79, 95% CI = 0.65-0.96), and age at first birth (OR = 0.85, 95% CI = 0.74-0.98), were significantly associated with a lower risk of overall lung cancer. On the contrary, non-natural menopause was significantly associated with higher lung cancer risk (OR = 1.52, 95% CI = 1.25-1.86). Among never-smokers, a significant negative association was found between parity and lung cancer risk. Both parity and non-natural menopause were statistically significant in case-control studies. Conclusion: These results suggest that certain reproductive factors may be associated with lung cancer risk. Future studies should further validate the associations, and investigate the underlying mechanisms. © 2020 The Author(s). | Source Title: | BMC Public Health | URI: | https://scholarbank.nus.edu.sg/handle/10635/197471 | ISSN: | 14712458 | DOI: | 10.1186/s12889-020-09530-7 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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