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Title: Three-year outcomes of simultaneous accelerated corneal crosslinking and femto-lasik for the treatment of high myopia in asian eyes
Authors: Lim, L. 
Lim, E.W.L.
Rosman, M. 
Koh, J.C.W.
Htoon, H.M. 
Keywords: Cross-linking
Refractive surgery
Issue Date: 2020
Publisher: Dove Medical Press Ltd
Citation: Lim, L., Lim, E.W.L., Rosman, M., Koh, J.C.W., Htoon, H.M. (2020). Three-year outcomes of simultaneous accelerated corneal crosslinking and femto-lasik for the treatment of high myopia in asian eyes. Clinical Ophthalmology 14 : 2865-2872. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial 4.0 International
Abstract: Purpose: To determine the long-term visual outcomes of simultaneous femtosecond laser-assisted laser in situ keratomileusis (femto-LASIK) and accelerated cross-linking (CXL) [LASIK Xtra] for the treatment of high myopia. Patients and Methods: All 163 consecutive eyes of 85 patients who underwent LASIK Xtra for the treatment of high myopia and/or myopic astigmatism (spherical equivalent ? ?6.00 D) in Singapore National Eye Centre from the years 2013 to 2017 were included in this retrospective case series. Post-operative follow-up was up to 3 years. Results: Of the 163 eyes, 67 were followed up for 1 year (mean 12.9 months), 69 for 2 years (mean 24.0 months) and 43 for 3 years (mean 36.4 months). Overall mean follow-up was 22.8 months (9–46 months). The mean pre-operative spherical equivalent (SE) was ?8.60 ± 1.47 D [range: ?11.75 to ?4.75] (n = 163) and mean attempted correction SE was ?8.84 ± 1.41 D [range: ?11.88 to ?5.25]. Most eyes (>95%) maintained an uncorrected distance visual acuity of 6/12 or better over 3 years. Visual outcomes were predictable with ?95% of eyes achieving a SE correction within ± 1D of attempted correction over 3 years. There was a mild regression in SE refraction over 3 years with a mean of ?0.10 ± 0.45 D three years post-operatively (p = 0.03). The safety index was >1.05 at 3 years follow-up. There were no significant post-operative complications though 24 eyes had mild haze and 2 eyes had grade 1 diffuse lamellar keratitis that resolved within 1 month. Conclusion: Our 3-year LASIK Xtra results show favorable safety, efficacy, predictability and stability outcomes in Asian patients with high myopia. © 2020 Lim et al.
Source Title: Clinical Ophthalmology
ISSN: 11775467
DOI: 10.2147/OPTH.S260088
Rights: Attribution-NonCommercial 4.0 International
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