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https://doi.org/10.2196/14802
Title: | Lifestyle intervention enabled by mobile technology on weight loss in patients with nonalcoholic fatty liver disease: Randomized controlled trial | Authors: | Lim, S.L. Johal, J. Ong, K.W. Han, C.Y. Chan, Y.H. Lee, Y.M. Loo, W.M. |
Keywords: | Diet Lifestyle intervention Liver enzymes MHealth Mobile app, weight loss NAFLD |
Issue Date: | 2020 | Publisher: | JMIR Publications Inc. | Citation: | Lim, S.L., Johal, J., Ong, K.W., Han, C.Y., Chan, Y.H., Lee, Y.M., Loo, W.M. (2020). Lifestyle intervention enabled by mobile technology on weight loss in patients with nonalcoholic fatty liver disease: Randomized controlled trial. JMIR mHealth and uHealth 8 (4) : e14802. ScholarBank@NUS Repository. https://doi.org/10.2196/14802 | Rights: | Attribution 4.0 International | Abstract: | Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) reaches up to 30% in the Asian adult population, with a higher prevalence in obese patients. Weight reduction is typically recommended for patients at high risk or diagnosed with NAFLD, but is a challenge to achieve. Objective: We aimed to evaluate the effect of a lifestyle intervention with a mobile app on weight loss in NAFLD patients. Methods: This prospective randomized controlled trial included 108 adults with NAFLD confirmed by steatosis on ultrasound and a body mass index ?23 kg/m2 who were recruited from a fatty liver outpatient clinic. The patients were randomly allocated to either a control group (n=53) receiving standard care, consisting of dietary and lifestyle advice by a trained nurse, or an intervention group (n=55) utilizing the Nutritionist Buddy (nBuddy) mobile app in addition to receiving dietary and lifestyle advice by a dietitian. Body weight, alanine aminotransferase (ALT), aspartate aminotransferase (AST), waist circumference, and blood pressure were measured at baseline, and then at 3 and 6 months. Intention-to-treat and per-protocol analyses were used for statistical comparisons. Results: The intervention group had a 5-fold higher likelihood (relative risk 5.2, P=.003, 95% CI 1.8-15.4) of achieving ?5% weight loss compared to the control group at 6 months. The intervention group also showed greater reductions in weight (mean 3.2, SD 4.1 kg vs mean 0.5, SD 2.9 kg; P<.001), waist circumference (mean 2.9, SD 5.0 cm vs mean –0.7, SD 4.4 cm; P<.001), systolic blood pressure (mean 12.4, SD 14.8 mmHg vs mean 2.4, SD 12.4 mmHg; P=.003), diastolic blood pressure (mean 6.8, SD 8.9 mmHg vs mean –0.9, SD 10.0 mmHg; P=.001), ALT (mean 33.5, SD 40.4 IU/L vs mean 11.5, SD 35.2 IU/L; P=.004), and AST (mean 17.4, SD 27.5 U/L vs mean 7.4, SD 17.6 IU/L, P=.03) at 6 months. Conclusions: Lifestyle intervention enabled by a mobile app can be effective in improving anthropometric indices and liver enzymes in patients with NAFLD. This treatment modality has the potential to be extended to a larger population scale. ©Su Lin Lim, Jolyn Johal, Kai Wen Ong, Chad Yixian Han, Yiong Huak Chan, Yin Mei Lee, Wai Mun Loo. | Source Title: | JMIR mHealth and uHealth | URI: | https://scholarbank.nus.edu.sg/handle/10635/196753 | ISSN: | 22915222 | DOI: | 10.2196/14802 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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